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DTSTART;TZID=America/Los_Angeles:20231009T093000
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UID:10000416-1696843800-1696878000@brain.uci.edu
SUMMARY:AI & Biomedicine Symposium: AI and Neuroscience
DESCRIPTION:This year’s annual Southern California AI and Biomedicine Symposium will focus on AI and Neuroscience.  The event is co-sponsored by the UCI Institute for Genomics and Bioinformatics and the UCI Center for the Neurobiology of Learning and Memory. The free event includes a full day of talks\, lunch\, and reception. RSVP soon as space is limited. \nDownload Event Flyer
URL:https://brain.uci.edu/event/ai-biomedicine-symposium-ai-and-neuroscience/
LOCATION:Calit2 Auditorium\, 4100 Calit2 Building\, Irvine\, Irvine
CATEGORIES:Faculty,Scientific,Staff,Students,Students, Faculty, Staff Only
ATTACH;FMTTYPE=image/jpeg:https://brain.uci.edu/wp-content/uploads/sites/49/2023/08/ai-biomedical-symposium.jpg
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BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20231017T110000
DTEND;TZID=America/Los_Angeles:20231017T120000
DTSTAMP:20260404T161254
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UID:10000426-1697540400-1697544000@brain.uci.edu
SUMMARY:Mayank Mehta\, Ph.D.
DESCRIPTION:CNLM Colloquium Series \nHippocampus 2.0: Three simple rules \nJoin the Center for the Neurobiology of Learning and Memory (CNLM) for a hybrid event featuring Dr. Mayank Mehta\, professor of physics\, astronomy\, neurology\, and neurobiology at UCLA. \nThis event will be held in-person in the Herklotz Conference Center and virtually via Zoom. \n \nDescription: \nThe hippocampus is implicated in many learning and memory disorders including Alzheimer’s. Dozens of drugs have cured these in mice but failed in humans. Hippocampal neurons in rodents show robust spatial selectivity. Hence\, the standard test of hippocampal function in mice is the Morris Water Maze\, an allocentric spatial memory task. However\, in freely behaving primates\, hippocampal neurons show very little spatial selectivity. Further\, hippocampal damage in humans causes profound non-spatial\, egocentric\, episodic memory deficits too\, whose neurophysiological analog in rodents is unclear. We propose a novel theory of hippocampal function\, Hippocampus 2.0\, which can reconcile these long-standing differences and provide several experimental tests of this theory. The results provide a unified framework for probing hippocampal function\, which could improve translation of therapies from mice to humans.
URL:https://brain.uci.edu/event/mayank-mehta-ph-d/
LOCATION:CNLM Herklotz Conference Center and Virtually via Zoom
CATEGORIES:Faculty,Scientific,Staff,Students,Students, Faculty, Staff Only
ATTACH;FMTTYPE=image/jpeg:https://brain.uci.edu/wp-content/uploads/sites/49/2023/09/1516960566877.jpeg
ORGANIZER;CN="UCI Center for the Neurobiology of Learning and Memory":MAILTO:memory@uci.edu
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BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20231024T110000
DTEND;TZID=America/Los_Angeles:20231024T120000
DTSTAMP:20260404T161254
CREATED:20230928T212745Z
LAST-MODIFIED:20231012T030909Z
UID:10000424-1698145200-1698148800@brain.uci.edu
SUMMARY:Roger Nicoll\, M.D.
DESCRIPTION:Join the Center for the Neurobiology of Learning and Memory (CNLM) and the Department of Anatomy and Neurobiology for a hybrid event featuring Dr. Roger Nicoll\, professor of cellular and molecular pharmacology at the University of California\, San Francisco. \nThe Biochemistry of Memory: A (not so) New and Specific Hypothesis \nEvent is jointly sponsored through the CNLM Colloquium Series and the Anatomy and Neurobiology Seminar Series. \nThis event will be held in-person in the Herklotz Conference Center and virtually via Zoom. \n \nDescription: \n\nCaMKII and long-term potentiation (LTP) were discovered within a decade of each other and have been inextricably intertwined ever since. In 1984 Francis Crick proposed that a memory molecule should possess two properties. First\, it should be a multimeric protein with identical subunits that can phosphorylate one another. Second\, to address how memories outlast molecular turnover he proposed that naïve unphosphorylated subunits could exchange into the phosphorylated multimer and become phosphorylated. Within two years biochemical studies established that CaMKII satisfied the first prediction. Recent biochemical studies have shown that unphosphorylated CaMKII subunits can exchange into phosphorylated CaMKII multimers\, thus satisfying Crick’s second prediction. My talk will focus on linking the biochemical properties of CaMKII to LTP. I will show that the autophosphorylation of CaMKII maintains LTP (memory) by establishing a stable CaMKII/NMDA receptor complex\, resulting in the synaptic capture of AMPA receptors. LTP survives the protein turnover of CaMKII\, which is complete within 2 weeks\, by its phosphorylation of newly synthesized naïve CaMKII molecules.
URL:https://brain.uci.edu/event/roger-nicoll-m-d/
LOCATION:CNLM Herklotz Conference Center and Virtually via Zoom
CATEGORIES:Faculty,Scientific,Staff,Students
ATTACH;FMTTYPE=image/jpeg:https://brain.uci.edu/wp-content/uploads/sites/49/2023/09/Roger-Nicoll-464x464-1.jpg
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