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SUMMARY:2024 Second Annual Symposium for the Center for Neurotherapeutics
DESCRIPTION:The purpose of the Symposium will be to familiarize attendees with the UCI Center for\nNeurotherapeutics and introduce attendees to the exciting translational\nneuroscience research happening right on our campus and in labs across the country. We\nhope that attendees will: \n\nLearn about the vision that drives us at the UCI Center for Neurotherapeutics and our\nongoing effort to advance drug development on campus.\nBecome acquainted with cutting-edge approaches being applied to develop innovative\nmodels and novel therapeutic solutions for neurological diseases. Lecture topics will\ninclude drug discovery and high-throughput screening methods to identify rational\ndrug targets. Experts from diverse disciplines will explain how they are tackling the\nchallenge of delivering small molecules and biological agents across the blood-brain\nbarrier.\nAppreciate the many opportunities for cross-disciplinary interaction and collaboration\nin this field. Our number one core value at the UCI Center for Neurotherapeutics is to\npromote collaboration across campus\, especially between faculty in the physical\nsciences and the biological sciences. We believe that only by combining such multi-\ndisciplinary expertise and diverse perspectives will it be possible to unlock new\navenues of discovery and accelerate progress toward developing meaningful solutions\nfor therapy development.\n\nOur exceptional line-up of guest speakers and UCI faculty speakers include: \n\nAnabella Villalobos (Biogen); Neurological/Rare Disease Therapies\nDonna Huryn (University of Pennsylvania); Academic Drug Discovery Challenges\nEthan Lippmann (Vanderbilt); siRNA Brain Delivery via Albumin\nSu Guo (UC San Francisco); GPCR Targeting in Parkinson’s\nHang Lu (Georgia Tech); Microtechnology & AI in Drug Screening\n Errol Arkilic (UC Irvine); Beall Applied Innovation\nLeslie Thompson (UC Irvine); Huntington’s Disease Treatment Advances\nJennifer Prescher (UC Irvine); Nature-Inspired Imaging Tools\nChristopher Hughes (UC Irvine); Blood-Brain Barrier Neurovascular Model\nMelanie Cocco (UC Irvine); Voxelotor for Red Blood Cell Modulation\n\nWhether you are a student\, postdoctoral trainee\, faculty member\, or staff member\, we\nencourage you to join us\, so please mark your calendars! \nRegistration is free! \nPlease register by Friday\, September 27\, 2024.
URL:https://brain.uci.edu/event/2024-second-annual-symposium-for-the-center-for-neurotherapeutics/
LOCATION:Samueli Integrative Health Institute Sue Gross Auditorium\, 856 Health Sciences Quad\, Irvine\, 92697\, United States
CATEGORIES:All,Community,Faculty,Scientific,Staff,Students,Students, Faculty, Staff Only
ATTACH;FMTTYPE=image/png:https://brain.uci.edu/wp-content/uploads/sites/49/2024/08/Picture1.png
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DTSTART;TZID=America/Los_Angeles:20241011T130000
DTEND;TZID=America/Los_Angeles:20241011T170000
DTSTAMP:20260417T142944
CREATED:20240925T222627Z
LAST-MODIFIED:20240925T223103Z
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SUMMARY:Masakazu Agetsuma\, Ph.D.
DESCRIPTION:The Center for Neural Circuit Mapping will host guest speaker Dr. Masakazu Agetsuma\, Associate Professor of Neuroscience at the National Institute for Physiological Sciences\, Japan \n “Activity-dependent organization of prefrontal hub-networks for associative learning and signal transformation” \nAssociative learning is crucial for adapting to environmental changes. Interactions among neuronal populations involving the dorso-medial prefrontal cortex (dmPFC) in rodents are proposed to regulate associative memory. Although neural network remodeling is generally believed to underlie learning and memory\, how this process occurs to store and process associative memory remains one of the most critical open questions in the field. To tackle this question\, we developed a pipeline for longitudinal two-photon imaging and mathematical dissection of neural population activities in mouse dmPFC during fear-conditioning procedures\, enabling us to detect learning-dependent changes in the dmPFC information coding and network topology. After confirming that the dmPFC contributes to the expression of the conditioned responses (CR) by chemogenetic silencing\, we recorded neural population activities and analyzed them by regularized regression methods and graphical modeling. We found that fear conditioning drove dmPFC reorganization to generate a neuronal ensemble encoding CR\, which was characterized by enhanced internal coactivity and functional connectivity. Importantly\, neurons strongly responding to unconditioned stimuli during fear conditioning subsequently became hubs of this novel network and revealed enhanced association with conditioned stimuli (CS) specifically in the CR ensemble\, which may work as an information-processing neural network implementing CS-triggered CR. Altogether\, we demonstrate learning-dependent dynamic modulation of population coding structured on the activity-dependent formation of the hub network within the dmPFC. features reflecting the biomechanical constraints and evolutionary origins of these motor control systems.”
URL:https://brain.uci.edu/event/masakazu-agetsuma-phd/
LOCATION:Plumwood House Room 166\, 1003 Health Sciences Rd\, Irvine\, CA 92617\, Irvine\, CA\, 92697-3800\, United States
CATEGORIES:Faculty,Scientific,Staff,Students,Students, Faculty, Staff Only
ATTACH;FMTTYPE=image/png:https://brain.uci.edu/wp-content/uploads/sites/49/2024/09/Jeffrey-Krichmar-Ph.D.-9.png
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BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20241016T193000
DTEND;TZID=America/Los_Angeles:20241016T203000
DTSTAMP:20260417T142944
CREATED:20240724T191849Z
LAST-MODIFIED:20240927T164530Z
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SUMMARY:Lisa Feldman Barrett\, Ph.D.
DESCRIPTION:The McGaugh-Gerard Lecture on Learning and Memory will host guest speaker Dr. Lisa Feldman Barrett\, University Distinguished Professor of Psychology at Northeastern University. \nThree Lessons About the Brain \n  \nEver wonder how your brain really works? Join us for the 3rd Annual McGaugh-Gerard Lecture on Learning and Memory by Dr. Lisa Feldman Barrett\, an author and expert in psychology and neuroscience\, as she breaks down three key ideas about the brain’s inner workings. In this talk\, you’ll learn: \n\nHow your brain’s most important job is keeping your body running smoothly.\nHow your brain is constantly predicting what will happen next rather than reacting to the world.\nHow feeling and thinking and even seeing follow from your brain’s plan for action; your brain prepares your behavior first and creates your lived experience in the process.\n\nDr. Barrett will show how these brain functions affect how you feel\, how you think\, and what you do.
URL:https://brain.uci.edu/event/lisa-feldman-barrett-ph-d/
LOCATION:Irvine Barclay Theater\, 4242 Campus Drive\, Irvine\, CA\, 92612\, United States
CATEGORIES:All,Community,Faculty,Scientific,Staff,Students,Students, Faculty, Staff Only
ATTACH;FMTTYPE=image/jpeg:https://brain.uci.edu/wp-content/uploads/sites/49/2024/07/feldman-300.jpg
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BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20241029T100000
DTEND;TZID=America/Los_Angeles:20241029T110000
DTSTAMP:20260417T142944
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SUMMARY:Yang Yang\, PhD
DESCRIPTION:UCI Epilepsy Research Center will host guest speaker Dr. Yang Yang\, Jack and Barbara McCoy Associate Professor from Purdue University\, for their EpiCenter Seminar. \n“SCN2A related autism and epilepsy: from mouse and hiPSC models to genetic medicine”
URL:https://brain.uci.edu/event/yang-yang-phd/
LOCATION:Plumwood House\, 1003 Health Sciences Rd\, Irvine\, CA 92617\, Irvine\, CA\, 92697\, United States
CATEGORIES:Faculty,Scientific,Staff,Students, Faculty, Staff Only
ATTACH;FMTTYPE=image/jpeg:https://brain.uci.edu/wp-content/uploads/sites/49/2024/10/thumbnail_Yang-profile-photo-F-e1728337550531.jpg
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