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DTSTART;TZID=America/Los_Angeles:20230426T080000
DTEND;TZID=America/Los_Angeles:20230430T170000
DTSTAMP:20260421T170002
CREATED:20230329T164104Z
LAST-MODIFIED:20230329T164104Z
UID:10000398-1682496000-1682874000@brain.uci.edu
SUMMARY:LEARNMEM2023
DESCRIPTION:Join the Center for the Neurobiology of Learning and Memory for the 2023 International Conference on Learning and Memory (LEARNMEM™2023) on April 26-30\, 2023 in Huntington Beach\, CA. The Conference will be held in celebration of the 40th Anniversary of the Center for the Neurobiology of Learning and Memory (CNLM). \nLEARNMEM™2023 will feature keynote talks by distinguished speakers\, scientific symposia\, lightning talks\, open papers\, poster sessions as well as professional development and networking opportunities. \nThe conference will have a substantial impact on the field by accelerating the pace of team science and providing a unique networking opportunity for the next generation of leaders in neuroscience.
URL:https://brain.uci.edu/event/learnmem2023/
LOCATION:Waterfront Beach Resort\, 21100 Pacific Coast Highway\, Huntington Beach\, CA\, 92648\, United States
CATEGORIES:Faculty,Scientific,Staff,Students,Students, Faculty, Staff Only
ATTACH;FMTTYPE=image/jpeg:https://brain.uci.edu/wp-content/uploads/sites/49/2023/03/LearnMem2023RegistrationBanner-01-1536x831-1.jpg
ORGANIZER;CN="UCI Center for the Neurobiology of Learning and Memory":MAILTO:memory@uci.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230509T110000
DTEND;TZID=America/Los_Angeles:20230509T120000
DTSTAMP:20260421T170002
CREATED:20220922T152442Z
LAST-MODIFIED:20230329T210859Z
UID:10000345-1683630000-1683633600@brain.uci.edu
SUMMARY:Laura Ewell\, Ph.D.
DESCRIPTION:CNLM Colloquium UCI Spotlight Series \nJoin the CNLM in a hybrid colloquium featuring Dr. Laura Ewell\, Assistant Professor of Anatomy and Neurobiology at UC Irvine. \nSparse to dense networks: pattern separation and completion in health and epilepsy. \nDescription: The attractor theory of memory posits that CA3\, the recurrent network at the core of the hippocampus\, is capable of learning\, storing\, and recalling ensembles of neurons that represent experience. In healthy conditions there are constraints on the CA3 network that ensure that individual neural patterns comprise a small group of neurons that do not overlap with other patterns. One critical constraint called pattern separation works at the network level – and is thought to be performed by the dentate gyrus. In this talk\, I will be examining the network processes of pattern separation and pattern completion through the lens of temporal lobe epilepsy – a disease in which network codes shift from sparse to dense schemes. We will discuss single unit data from freely moving rodents (epilepsy models and healthy animals) and new tasks being developed by my laboratory to study these critical memory processes. \nThis event will be held in-person in the Herklotz Conference Center and virtually via Zoom.
URL:https://brain.uci.edu/event/laura-ewell-ph-d/
LOCATION:CNLM Herklotz Conference Center and Virtually via Zoom
CATEGORIES:Faculty,Scientific,Staff,Students
ATTACH;FMTTYPE=image/png:https://brain.uci.edu/wp-content/uploads/sites/49/2022/09/image.png
ORGANIZER;CN="UCI Center for the Neurobiology of Learning and Memory":MAILTO:memory@uci.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230523T110000
DTEND;TZID=America/Los_Angeles:20230523T120000
DTSTAMP:20260421T170003
CREATED:20220922T152246Z
LAST-MODIFIED:20230411T221331Z
UID:10000344-1684839600-1684843200@brain.uci.edu
SUMMARY:Leslie Thompson\, Ph.D.
DESCRIPTION:CNLM Colloquium UCI Spotlight Series \nJoin the CNLM in a hybrid colloquium featuring Dr. Leslie Thompson\, Professor of Psychiatry & Human Behavior at UC Irvine. \nHuntington’s disease research and therapeutics; the long winding road \nHuntington’s disease is a devastating neurodegenerative disease that typically strikes in the prime of life with no disease modifying treatment. It is caused by a repeat expansion within the coding region of the protein Huntingtin which is expressed throughout the body and is required for a vast array of cellular processes. The disease mutation causes both a gain of function and loss of normal function which adds significant complexity to understanding disease mechanisms and advancing therapeutics. In this talk I will describe three vignettes relating to disease mechanisms and therapeutic approaches undertaken in the laboratory. \nThis event will be held in-person in the Herklotz Conference Center and virtually via Zoom.
URL:https://brain.uci.edu/event/leslie-thompson-ph-d/
LOCATION:CNLM Herklotz Conference Center and Virtually via Zoom
CATEGORIES:Faculty,Scientific,Staff,Students
ATTACH;FMTTYPE=image/jpeg:https://brain.uci.edu/wp-content/uploads/sites/49/2022/09/image-2.jpeg
ORGANIZER;CN="UCI Center for the Neurobiology of Learning and Memory":MAILTO:memory@uci.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230525T150000
DTEND;TZID=America/Los_Angeles:20230525T170000
DTSTAMP:20260421T170003
CREATED:20230327T223159Z
LAST-MODIFIED:20230327T223159Z
UID:10000397-1685026800-1685034000@brain.uci.edu
SUMMARY:2023 CNLM Award Ceremony
DESCRIPTION:Join the Center for the Neurobiology of Learning and Memory (CNLM) for the 2023 CNLM Awards Ceremony. \nThe CNLM offers awards to exceptional postdoctoral researchers\, graduate trainees\, undergraduates students\, and faculty.  Awardees will be presented with a plaque and $1\,000 stipend and will be invited to present their work in brief Elevator Pitch format to the UCI academic community and the public at our annual CNLM Awards Ceremony. \nApplications for the 2023 CNLM Awards are due May 3rd.\n\n \nFor more information\, please visit: https://cnlm.uci.edu/awards/
URL:https://brain.uci.edu/event/2023-cnlm-award-ceremony/
LOCATION:CNLM Herklotz Conference Center\, Irvine\, CA\, 92697\, United States
CATEGORIES:All,Community,Faculty,Staff,Students
ATTACH;FMTTYPE=image/jpeg:https://brain.uci.edu/wp-content/uploads/sites/49/2023/03/cnlm-award-home-page-1.jpg
ORGANIZER;CN="UCI Center for the Neurobiology of Learning and Memory":MAILTO:memory@uci.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230711T160000
DTEND;TZID=America/Los_Angeles:20230711T170000
DTSTAMP:20260421T170003
CREATED:20230630T170936Z
LAST-MODIFIED:20230630T171020Z
UID:10000414-1689091200-1689094800@brain.uci.edu
SUMMARY:Read Montague\, Ph.D.
DESCRIPTION:Reinforcement Learning\, Monoamines and the effort to connect neurochemical dynamics to Human Perception\n\nJoin the Conte Center @ UCI for their seminar series featuring Dr. Read Montague\, Virginia Tech Carilion Vernon Mountcastle Research Professor and director of the Center for Human Neuroscience Research at the Franlin Biomedical Research Institute.
URL:https://brain.uci.edu/event/read-montague-ph-d/
LOCATION:Plumwood House\, 1003 Health Sciences Rd\, Irvine\, CA 92617\, Irvine\, CA\, 92697\, United States
CATEGORIES:Faculty,Scientific,Students,Students, Faculty, Staff Only
ATTACH;FMTTYPE=image/png:https://brain.uci.edu/wp-content/uploads/sites/49/2023/06/read-montegue.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230909T150000
DTEND;TZID=America/Los_Angeles:20230909T180000
DTSTAMP:20260421T170003
CREATED:20230621T181326Z
LAST-MODIFIED:20230621T181326Z
UID:10000413-1694271600-1694282400@brain.uci.edu
SUMMARY:Down Syndrome Showcase
DESCRIPTION:A celebration of the creative and artistic talents of children and adults with Down Syndrome and an opportunity to learn about the factors that impact the health and well-being of people with Down Syndrome \nTalent Show and Art Exhibits: Anyone with Down syndrome who would like to perform on stage or display their art/crafts should contactcoordinator@dsaoc.org. Sign-ups are on a first-come\, first-served basis. \nPoster Presentations: Any UCI student or scholar interested in presenting their scientific findings related to Down syndrome should contact ndiprosp@uci.edu. \nAdmission and parking: Free. Every guest\, performer\, and exhibitor must have a ticket. Order through the theater box office: www.thebarclay.org. \nFor more information: Visit cfar-ds.uci.edu or e-mail: cfar-ds@uci.edu  \nLight refreshments will be served. 
URL:https://brain.uci.edu/event/down-syndrome-showcase/
LOCATION:Irvine Barclay Theater\, 4242 Campus Drive\, Irvine\, CA\, 92612\, United States
CATEGORIES:All,Community,Faculty,Scientific,Staff,Students
ATTACH;FMTTYPE=image/png:https://brain.uci.edu/wp-content/uploads/sites/49/2023/06/down-syndrome-showcase.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20231009T093000
DTEND;TZID=America/Los_Angeles:20231009T190000
DTSTAMP:20260421T170003
CREATED:20230804T180405Z
LAST-MODIFIED:20230804T181633Z
UID:10000416-1696843800-1696878000@brain.uci.edu
SUMMARY:AI & Biomedicine Symposium: AI and Neuroscience
DESCRIPTION:This year’s annual Southern California AI and Biomedicine Symposium will focus on AI and Neuroscience.  The event is co-sponsored by the UCI Institute for Genomics and Bioinformatics and the UCI Center for the Neurobiology of Learning and Memory. The free event includes a full day of talks\, lunch\, and reception. RSVP soon as space is limited. \nDownload Event Flyer
URL:https://brain.uci.edu/event/ai-biomedicine-symposium-ai-and-neuroscience/
LOCATION:Calit2 Auditorium\, 4100 Calit2 Building\, Irvine\, Irvine
CATEGORIES:Faculty,Scientific,Staff,Students,Students, Faculty, Staff Only
ATTACH;FMTTYPE=image/jpeg:https://brain.uci.edu/wp-content/uploads/sites/49/2023/08/ai-biomedical-symposium.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20231017T110000
DTEND;TZID=America/Los_Angeles:20231017T120000
DTSTAMP:20260421T170003
CREATED:20230929T190105Z
LAST-MODIFIED:20231009T214316Z
UID:10000426-1697540400-1697544000@brain.uci.edu
SUMMARY:Mayank Mehta\, Ph.D.
DESCRIPTION:CNLM Colloquium Series \nHippocampus 2.0: Three simple rules \nJoin the Center for the Neurobiology of Learning and Memory (CNLM) for a hybrid event featuring Dr. Mayank Mehta\, professor of physics\, astronomy\, neurology\, and neurobiology at UCLA. \nThis event will be held in-person in the Herklotz Conference Center and virtually via Zoom. \n \nDescription: \nThe hippocampus is implicated in many learning and memory disorders including Alzheimer’s. Dozens of drugs have cured these in mice but failed in humans. Hippocampal neurons in rodents show robust spatial selectivity. Hence\, the standard test of hippocampal function in mice is the Morris Water Maze\, an allocentric spatial memory task. However\, in freely behaving primates\, hippocampal neurons show very little spatial selectivity. Further\, hippocampal damage in humans causes profound non-spatial\, egocentric\, episodic memory deficits too\, whose neurophysiological analog in rodents is unclear. We propose a novel theory of hippocampal function\, Hippocampus 2.0\, which can reconcile these long-standing differences and provide several experimental tests of this theory. The results provide a unified framework for probing hippocampal function\, which could improve translation of therapies from mice to humans.
URL:https://brain.uci.edu/event/mayank-mehta-ph-d/
LOCATION:CNLM Herklotz Conference Center and Virtually via Zoom
CATEGORIES:Faculty,Scientific,Staff,Students,Students, Faculty, Staff Only
ATTACH;FMTTYPE=image/jpeg:https://brain.uci.edu/wp-content/uploads/sites/49/2023/09/1516960566877.jpeg
ORGANIZER;CN="UCI Center for the Neurobiology of Learning and Memory":MAILTO:memory@uci.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20231024T110000
DTEND;TZID=America/Los_Angeles:20231024T120000
DTSTAMP:20260421T170003
CREATED:20230928T212745Z
LAST-MODIFIED:20231012T030909Z
UID:10000424-1698145200-1698148800@brain.uci.edu
SUMMARY:Roger Nicoll\, M.D.
DESCRIPTION:Join the Center for the Neurobiology of Learning and Memory (CNLM) and the Department of Anatomy and Neurobiology for a hybrid event featuring Dr. Roger Nicoll\, professor of cellular and molecular pharmacology at the University of California\, San Francisco. \nThe Biochemistry of Memory: A (not so) New and Specific Hypothesis \nEvent is jointly sponsored through the CNLM Colloquium Series and the Anatomy and Neurobiology Seminar Series. \nThis event will be held in-person in the Herklotz Conference Center and virtually via Zoom. \n \nDescription: \n\nCaMKII and long-term potentiation (LTP) were discovered within a decade of each other and have been inextricably intertwined ever since. In 1984 Francis Crick proposed that a memory molecule should possess two properties. First\, it should be a multimeric protein with identical subunits that can phosphorylate one another. Second\, to address how memories outlast molecular turnover he proposed that naïve unphosphorylated subunits could exchange into the phosphorylated multimer and become phosphorylated. Within two years biochemical studies established that CaMKII satisfied the first prediction. Recent biochemical studies have shown that unphosphorylated CaMKII subunits can exchange into phosphorylated CaMKII multimers\, thus satisfying Crick’s second prediction. My talk will focus on linking the biochemical properties of CaMKII to LTP. I will show that the autophosphorylation of CaMKII maintains LTP (memory) by establishing a stable CaMKII/NMDA receptor complex\, resulting in the synaptic capture of AMPA receptors. LTP survives the protein turnover of CaMKII\, which is complete within 2 weeks\, by its phosphorylation of newly synthesized naïve CaMKII molecules.
URL:https://brain.uci.edu/event/roger-nicoll-m-d/
LOCATION:CNLM Herklotz Conference Center and Virtually via Zoom
CATEGORIES:Faculty,Scientific,Staff,Students
ATTACH;FMTTYPE=image/jpeg:https://brain.uci.edu/wp-content/uploads/sites/49/2023/09/Roger-Nicoll-464x464-1.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20231109T160000
DTEND;TZID=America/Los_Angeles:20231109T170000
DTSTAMP:20260421T170003
CREATED:20231027T200250Z
LAST-MODIFIED:20231027T201325Z
UID:10000445-1699545600-1699549200@brain.uci.edu
SUMMARY:Flavio Donato\, Ph.D.
DESCRIPTION:Conte Center @ UCI Seminar Series \nMemory dynamics through the divergent recruitment of developmentally-defined hippocampal traces \nJoin the Conte Center @ UCI for a seminar by Dr. Flavio Donato\, assistant professor of neurobiology at the University of Basel.
URL:https://brain.uci.edu/event/flavio-donato-ph-d/
LOCATION:Plumwood House\, 1003 Health Sciences Rd\, Irvine\, CA 92617\, Irvine\, CA\, 92697\, United States
CATEGORIES:Faculty,Scientific,Staff,Students, Faculty, Staff Only
ATTACH;FMTTYPE=image/jpeg:https://brain.uci.edu/wp-content/uploads/sites/49/2023/10/falvio-donato.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20231128T110000
DTEND;TZID=America/Los_Angeles:20231128T120000
DTSTAMP:20260421T170003
CREATED:20231009T211005Z
LAST-MODIFIED:20231009T214419Z
UID:10000429-1701169200-1701172800@brain.uci.edu
SUMMARY:Anna K. Gillespie\, Ph.D.
DESCRIPTION:CNLM Colloquium Series \nSteps toward exploring the therapeutic potential of hippocampal replay \nJoin the Center for the Neurobiology of Learning and Memory (CNLM) for a hybrid event featuring Dr. Anna Gillespie\, assistant professor of biological structure\, lab medicine\, and pathology at University of Washington. This event will be held in-person in the Herklotz Conference Center and virtually via Zoom. \n \nDescription: \nExecuting memory-guided behavior requires storage of information about experience and later recall of that information to inform choices. Hippocampal sharp-wave ripple (SWR) events are associated with the time-compressed “replay” of representations of past experience\, and multiple correlative and causal studies have demonstrated that SWRs critically contribute to these cognitive functions. Consistent with its role in memory processes\, changes in SWRs have been reported concurrent with memory impairment in several rodent models of Alzheimer’s disease. Rescuing replay in Alzheimer’s could thus improve memory symptoms; however\, our current options for promoting physiologically relevant replay are quite limited. To address this gap\, we developed a neurofeedback paradigm for rats in which the real-time detection of SWRs triggers the delivery of positive reinforcement (food reward). In young adult animals\, this training protocol increased the prevalence of task-relevant replay during the targeted neurofeedback period by changing the temporal dynamics of SWR occurrence\, and was also associated with neural and behavioral forms of compensation after the targeted period. This work demonstrates that subjects can learn to use neurofeedback to modulate physiologically relevant patterns of hippocampal network activity and lays the foundation for future work in subjects with compromised replay\, such as rodent models of Alzheimer’s disease.
URL:https://brain.uci.edu/event/anna-k-gillespie-ph-d/
LOCATION:CNLM Herklotz Conference Center and Virtually via Zoom
CATEGORIES:Faculty,Scientific,Staff,Students,Students, Faculty, Staff Only
ATTACH;FMTTYPE=image/jpeg:https://brain.uci.edu/wp-content/uploads/sites/49/2023/10/anna-gillespie-250.jpg
ORGANIZER;CN="UCI Center for the Neurobiology of Learning and Memory":MAILTO:memory@uci.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20240206T110000
DTEND;TZID=America/Los_Angeles:20240206T120000
DTSTAMP:20260421T170003
CREATED:20231009T213853Z
LAST-MODIFIED:20231205T181600Z
UID:10000431-1707217200-1707220800@brain.uci.edu
SUMMARY:Elizabeth A. Buffalo\, Ph.D.
DESCRIPTION:CNLM Colloquium Series \nJoin the Center for the Neurobiology of Learning and Memory (CNLM) for a hybrid event featuring Dr. Elizabeth A. Buffalo\, professor and chair of physiology and biophysics at the University of Washington. \nThis event will be held in-person in the Herklotz Conference Center and virtually via Zoom. \nNeural Dynamics of Memory Formation in the Primate Hippocampus  \n \nDescription:  \nOur understanding of the hippocampus has been framed by two landmark discoveries: the discovery by Scoville and Millner that hippocampal damage causes profound and persistent amnesia and the discovery by O’Keefe and Dostrovsky of hippocampal place cells in rodents. However\, it has been unclear to what extent spatial representations are present in the primate brain and how to reconcile these representations with the known mnemonic function of this region. I will discuss a series of experiments that have examined neural activity in the hippocampus in monkeys performing behavioral tasks including foraging and spatial memory tasks in a virtual environment. These data demonstrate that behavioral task structure has a significant influence on hippocampal activity\, with neurons responding to all salient events within the task. Taken together\, these data are consistent with the idea that activity in the hippocampus tracks ongoing experience in support of memory formation.
URL:https://brain.uci.edu/event/elizabeth-buffalo-ph-d/
LOCATION:CNLM Herklotz Conference Center and Virtually via Zoom
CATEGORIES:Faculty,Scientific,Staff,Students,Students, Faculty, Staff Only
ATTACH;FMTTYPE=image/jpeg:https://brain.uci.edu/wp-content/uploads/sites/49/2023/10/beth-buffalo-250.jpg
ORGANIZER;CN="UCI Center for the Neurobiology of Learning and Memory":MAILTO:memory@uci.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20240215T110000
DTEND;TZID=America/Los_Angeles:20240215T120000
DTSTAMP:20260421T170003
CREATED:20240202T182333Z
LAST-MODIFIED:20240202T182333Z
UID:10000477-1707994800-1707998400@brain.uci.edu
SUMMARY:Garret Anderson\, PhD
DESCRIPTION:The department of Anatomy & Neurobiology will host guest speaker Garret Anderson from UC Riverside\, who will give a talk on ““Latrophilin cell-type specific expression and implications for neural circuit development”
URL:https://brain.uci.edu/event/garret-anderson-phd/
LOCATION:Plumwood House\, 1003 Health Sciences Rd\, Irvine\, CA 92617\, Irvine\, CA\, 92697\, United States
CATEGORIES:Community,Faculty,Scientific,Staff,Students
ATTACH;FMTTYPE=image/png:https://brain.uci.edu/wp-content/uploads/sites/49/2024/02/Capture.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20240305T110000
DTEND;TZID=America/Los_Angeles:20240305T120000
DTSTAMP:20260421T170003
CREATED:20231009T215006Z
LAST-MODIFIED:20240229T212335Z
UID:10000432-1709636400-1709640000@brain.uci.edu
SUMMARY:J. David Jentsch\, Ph.D.
DESCRIPTION:CNLM Colloquium Series \nJoin the Center for the Neurobiology of Learning and Memory (CNLM) for a hybrid event featuring Dr. J. David Jentsch\, Distinguished Professor and Chair of psychology at Binghamton University. This event will be held in-person in the Herklotz Conference Center and virtually via Zoom. \nDiversity to the rescue: Identifying novel molecular regulators of addiction liability
URL:https://brain.uci.edu/event/j-david-jentsch-ph-d/
LOCATION:CNLM Herklotz Conference Center and Virtually via Zoom
CATEGORIES:Faculty,Scientific,Staff,Students,Students, Faculty, Staff Only
ATTACH;FMTTYPE=image/jpeg:https://brain.uci.edu/wp-content/uploads/sites/49/2023/10/jjentsch-2.jpg
ORGANIZER;CN="UCI Center for the Neurobiology of Learning and Memory":MAILTO:memory@uci.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20240312T110000
DTEND;TZID=America/Los_Angeles:20240312T120000
DTSTAMP:20260421T170003
CREATED:20231009T215405Z
LAST-MODIFIED:20240130T163208Z
UID:10000433-1710241200-1710244800@brain.uci.edu
SUMMARY:Christian Bravo Rivera\, Ph.D.
DESCRIPTION:CNLM Colloquium Series \nJoin the Center for the Neurobiology of Learning and Memory (CNLM) for a hybrid event featuring Dr. Christian Bravo Rivera\, assistant professor of psychiatry\, anatomy\, and neurobiology. This event will be held in-person in the Herklotz Conference Center and virtually via Zoom. \nNeural circuits mediating reward approach and punishment avoidance conflict  \nReward is often present in risky environments\, requiring individuals to weigh the benefits of rewards against the associated risks. There are individuals that are unable to choose an appropriate response during risky reward opportunities and thus exhibit extreme avoidance or risky behaviors that can severely impair quality of life or endanger people. It is therefore necessary to characterize how neurons mediate reward approach and threat avoidance conflict. Here\, we adapted the platform-mediated avoidance conflict task (Bravo-Rivera et al 2014; Bravo-Rivera et al 2021)\, such that water-deprived mice could nose-poke for a light-signaled water reward and avoid a tone-signaled foot-shock by stepping onto a safety platform away from the reward port. Optogenetic activation of GABAergic neurons in the ventral pallidum invigorated reward approach at the expense of receiving shocks. Photometry recordings of glutamatergic neurons in the ventral pallidum and in the lateral habenula during conflict revealed that these structures promote avoidance and become inhibited during conflicted reward approach. These results suggest that a pallidal-habenula circuit mediates motivational conflict. We also compared behavioral conflict in male and female mice. Interestingly\, females stepped on the platform earlier than males after tone onset and took longer to leave the platform after tone offset. Males received more shocks than females and received more water reward than females by the end conflict training. Moreover\, females exhibited more tone-induced freezing and exhibited more frequent darting than males. These results suggest that females exhibit more avoidance behavior and less reward approach than males in the face of approach/avoidance conflict.
URL:https://brain.uci.edu/event/christian-bravo-rivera-ph-d/
LOCATION:CNLM Herklotz Conference Center and Virtually via Zoom
CATEGORIES:Faculty,Scientific,Staff,Students,Students, Faculty, Staff Only
ATTACH;FMTTYPE=image/jpeg:https://brain.uci.edu/wp-content/uploads/sites/49/2023/10/christian-bravo-rivera250.jpg
ORGANIZER;CN="UCI Center for the Neurobiology of Learning and Memory":MAILTO:memory@uci.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20240314T110000
DTEND;TZID=America/Los_Angeles:20240314T120000
DTSTAMP:20260421T170003
CREATED:20240208T235302Z
LAST-MODIFIED:20240209T161652Z
UID:10000494-1710414000-1710417600@brain.uci.edu
SUMMARY:Krishna Jayant\, PhD
DESCRIPTION:The department of Anatomy & Neurobiology will host guest speaker Dr. Krishna Jayant\, an assistant professor from Purdue University. \nA translaminar space-time code supports touch-evoked traveling waves \nTraveling waves in mammalian cortex mediate vital aspects of animal cognition\, such as stimuli perception and working memory. Theoretical results suggest that these waves preserve timing and are critical for plasticity across long-range neural circuits. Therefore\, revealing the circuit mechanisms underlying sensory-evoked traveling waves is critical to understanding the neural basis of sensory perception. In this talk\, I will describe our recent efforts in using 2D nanotextured transparent ECoG style electrodes to map circuits orchestrating wave dynamics. Specifically\, by simultaneously mapping local-field-potentials and cellular ensemble dynamics (via 2P calcium imaging)\, we will describe the circuit features tied to traveling waves under active and passive whisker touch. We will show that in awake mice\, both passive and active whisker touch elicited traveling waves within and across barrels\, with both an early and late component lasting hundreds of milliseconds.  Strikingly\, wave dynamics reflected the value of the tactile stimulus\, and was found to be shaped by reinforcement learning. We will also describe how the late wave component is i) strongly modulated by motor feedback\, ii) complements a sparse ensemble pattern across layer 2/3 which we resolved via a balanced-state network model with distributed top-down feedback\, and iii) aligns with regenerative Layer 5 apical dendritic Ca2+ spikes. Our results establish a model in which translaminar spacetime patterns\, organized by motor cortical feedback\, sculpt touch-evoked traveling waves.
URL:https://brain.uci.edu/event/krishna-jayant-phd/
LOCATION:Plumwood House\, 1003 Health Sciences Rd\, Irvine\, CA 92617\, Irvine\, CA\, 92697\, United States
CATEGORIES:Community,Faculty,Scientific,Staff,Students
ATTACH;FMTTYPE=image/png:https://brain.uci.edu/wp-content/uploads/sites/49/2024/02/Untitled-design-48.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20240315T120000
DTEND;TZID=America/Los_Angeles:20240315T131500
DTSTAMP:20260421T170003
CREATED:20240131T220057Z
LAST-MODIFIED:20240131T220057Z
UID:10000472-1710504000-1710508500@brain.uci.edu
SUMMARY:Presidential Leadership and Disability
DESCRIPTION:The age of presidential candidates has become a salient concern\, but age is not the only physical factor that should concern citizens. Presidents can also suffer various forms of illness\, both physical and psychological. This talk highlights the nature of these concerns and how we might work to mitigate their impact on political outcomes. \nFree registration is open now: https://uci.zoom.us/webinar/register/WN_m5HtweYgSh6t9sGnAa_hOQ#/registration \nFor more details\, please visit: https://sites.uci.edu/centerforneuropolitics/
URL:https://brain.uci.edu/event/presidential-leadership-and-disability/
LOCATION:Zoom Webinar
CATEGORIES:All,Community,Faculty,Scientific,Staff,Students
ATTACH;FMTTYPE=image/jpeg:https://brain.uci.edu/wp-content/uploads/sites/49/2024/01/Neuropolitics-Social-Ad_FridayMarch5th2024_-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20240409T100000
DTEND;TZID=America/Los_Angeles:20240409T110000
DTSTAMP:20260421T170003
CREATED:20240125T235047Z
LAST-MODIFIED:20240327T223638Z
UID:10000469-1712656800-1712660400@brain.uci.edu
SUMMARY:Xiaoyin Chen\, Ph.D.
DESCRIPTION:Understanding cortical organization using in situ sequencing \nThe UCI Center for Neural Circuit Mapping will host Xiaoyin Chen\, PhD\, assistant investigator of the Barcoded Connectomics Program at the  Allen Institute.
URL:https://brain.uci.edu/event/xiaoyin-chen-phd/
LOCATION:Interdisciplinary Science and Engineering Building (ISEB) and Virtually Via Zoom\, 419 Physical Sciences Quad\, Irvine\, 92697\, United States
CATEGORIES:Faculty,Scientific,Staff,Students,Students, Faculty, Staff Only
ATTACH;FMTTYPE=image/png:https://brain.uci.edu/wp-content/uploads/sites/49/2024/01/Untitled-design-15.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20240409T110000
DTEND;TZID=America/Los_Angeles:20240409T120000
DTSTAMP:20260421T170003
CREATED:20231009T215849Z
LAST-MODIFIED:20240213T192635Z
UID:10000434-1712660400-1712664000@brain.uci.edu
SUMMARY:Nanthia Suthana\, Ph.D.
DESCRIPTION:Join the Center for the Neurobiology of Learning and Memory (CNLM) for a hybrid event featuring Dr. Nanthia Suthana\, associate professor-in-residence at the University of California\, Los Angeles. This event will be held in-person in the Herklotz Conference Center and virtually via Zoom. \nUnraveling Memories on the Go: Insights from Mobile Intracranial EEG Recordings in Humans \n \nDescription: \nRecent technology enables the study of deep brain activity during memory phenomena in ambulatory humans navigating through real or virtual environments. Through these methods\, we have shown dynamic modulation of hippocampal\, entorhinal\, and amygdala activity by factors like movement speed\, eye movements\, emotional valence and memory success. This presentation will provide an overview of these findings and explore potential clinical applications\, particularly in treating neuropsychiatric disorders such as post-traumatic stress disorder.
URL:https://brain.uci.edu/event/nanthia-suthana-ph-d/
LOCATION:CNLM Herklotz Conference Center and Virtually via Zoom
CATEGORIES:Faculty,Scientific,Staff,Students,Students, Faculty, Staff Only
ATTACH;FMTTYPE=image/jpeg:https://brain.uci.edu/wp-content/uploads/sites/49/2023/10/nanthia-suthana-profile.jpg
ORGANIZER;CN="UCI Center for the Neurobiology of Learning and Memory":MAILTO:memory@uci.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20240411T110000
DTEND;TZID=America/Los_Angeles:20240411T123000
DTSTAMP:20260421T170003
CREATED:20240206T192557Z
LAST-MODIFIED:20240327T222339Z
UID:10000492-1712833200-1712838600@brain.uci.edu
SUMMARY:Joshua Johansen\, PhD
DESCRIPTION:The department of Anatomy & Neurobiology will host guest speaker Dr. Joshua Johansen from the RIKEN Center for Brain Science \nConstructing Emotional Representations in the Brain \nDescription: \nInnately aversive experiences profoundly alter brain processing to produce emotional states which coordinate physiological and behavioral responses and instruct memory formation. However\, more complex emotions occur through an evaluation of the environment in the context of past experiences and the current physiological condition of the organism. My lab studies the neural circuits and cell coding mechanisms which translate aversive experiences into simple and complex emotional states in the brain to regulate memory formation and guide behavior. I will describe our recent work identifying a brainstem neural circuit which conveys both external-sensory and internal-motor features of innately aversive experiences to create a sensorimotor state in the amygdala for producing aversive memory formation. Contrasting with this bottom-up circuit\, we’ve also found that the medial prefrontal cortex encodes more complex emotional states by building an internal associative model to perform emotional inference through top-down projections to the amygdala. These studies support a new hierarchical circuit model of emotion in which sensory\, bodily and cognitive factors shape neural processing across distributed neural circuits to adaptively and flexibly control defensive responding and memory formation.
URL:https://brain.uci.edu/event/anatomy-neurobiology-seminar-dr-joshua-johansen/
LOCATION:Plumwood House\, 1003 Health Sciences Rd\, Irvine\, CA 92617\, Irvine\, CA\, 92697\, United States
CATEGORIES:Community,Faculty,Scientific,Staff,Students
ATTACH;FMTTYPE=image/jpeg:https://brain.uci.edu/wp-content/uploads/sites/49/2024/02/j.johansen.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20240416T110000
DTEND;TZID=America/Los_Angeles:20240416T120000
DTSTAMP:20260421T170003
CREATED:20240327T215151Z
LAST-MODIFIED:20240327T221827Z
UID:10000513-1713265200-1713268800@brain.uci.edu
SUMMARY:Semir Zeki\, FMedSci\, FRS
DESCRIPTION:Join the Center for the Neurobiology of Learning and Memory (CNLM) for an online event featuring Dr. Semir Zeki\, professor of neuroaesthetics at University College London. This event will be held virtually via Zoom. \nThe science of beauty \n \nThe experience of beauty is something that we all seek and are prepared to expend considerable energy and much money in trying to acquire. But what does it entail neurobiologically? If it is a subjective experience\, can it ever be measured? Are there\, or can there be\, any set of characteristics that render objects beautiful\, irrespective of culture and upbringing?I will address these questions from a neurobiological perspective. I will show that there cannot be a single characteristic or a single set of characteristics that can render any and every object beautiful because of the way in which our brains are organized to perceive the world. I will also show that there are\, in the perception of different attributes such as visual motion\, faces and bodies\, criteria which are not culture or education bound which can be said to enhance their beauty and to be critical to the experience of beauty when viewing them. Finally\, I will show that all works that are experienced as beautiful\, regardless of source (i.e. whether visual or musical or highly cognitive – as with mathematical beauty)\, have\, as a correlate\, activity in a specific part of the reward system of the emotional brain\, although the neural route used to reach that part of the brain varies\, depending on what is perceived. The intensity of activity there bears a quantitative relationship to the declared intensity of the experience of beauty\, thus enabling us to detect and quantify the neural correlates of a subjective experience.
URL:https://brain.uci.edu/event/semir-zeki-fmedsci-frs/
LOCATION:Zoom\, Irvine\, CA\, 92697\, United States
CATEGORIES:Faculty,Scientific,Staff,Students,Students, Faculty, Staff Only
ATTACH;FMTTYPE=image/png:https://brain.uci.edu/wp-content/uploads/sites/49/2024/03/Semir-Zeki.png
ORGANIZER;CN="UCI Center for the Neurobiology of Learning and Memory":MAILTO:memory@uci.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20240423T110000
DTEND;TZID=America/Los_Angeles:20240423T120000
DTSTAMP:20260421T170003
CREATED:20231009T220619Z
LAST-MODIFIED:20240313T230915Z
UID:10000436-1713870000-1713873600@brain.uci.edu
SUMMARY:Laura Colgin\, Ph.D.
DESCRIPTION:CNLM Colloquium Series \nJoin the Center for the Neurobiology of Learning and Memory (CNLM) for a hybrid event featuring Dr. Laura Colgin\, professor of neuroscience at the University of Texas at Austin. This event will be held in-person in the Herklotz Conference Center and virtually via Zoom. \nHippocampal place cell responses to spatial and non-spatial information \n \nDescription: \nThe hippocampus is a key brain network for episodic memory. Place cells are neurons in the hippocampus that fire in specific spatial locations known as place fields. This spatially selective firing is thought to code the “where” component of episodic memory. Yet\, episodic memories contain nonspatial information also. This talk will present results showing how different populations of hippocampal place cells respond to nonspatial aspects of an experience\, such as social stimuli or motivational context. The results may help explain how the hippocampus integrates different aspects of an experience into a coherent episodic memory.
URL:https://brain.uci.edu/event/laura-colgin-ph-d/
LOCATION:CNLM Herklotz Conference Center and Virtually via Zoom
CATEGORIES:Faculty,Scientific,Staff,Students,Students, Faculty, Staff Only
ATTACH;FMTTYPE=image/jpeg:https://brain.uci.edu/wp-content/uploads/sites/49/2023/10/Laura-Colgin.jpg
ORGANIZER;CN="UCI Center for the Neurobiology of Learning and Memory":MAILTO:memory@uci.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20240430T100000
DTEND;TZID=America/Los_Angeles:20240430T110000
DTSTAMP:20260421T170003
CREATED:20240201T201916Z
LAST-MODIFIED:20240327T225747Z
UID:10000475-1714471200-1714474800@brain.uci.edu
SUMMARY:Tian Lu\, Ph.D.
DESCRIPTION:Spatially resolved single-cell epigenomics and functional genomics \nThe Center for Neural Circuit Mapping (CNCM) will host Dr. Tian Lu\, a postdoctoral fellow in chemistry and chemical biology at Harvard University.
URL:https://brain.uci.edu/event/tian-lu/
LOCATION:Interdisciplinary Science and Engineering Building (ISEB) and Virtually Via Zoom\, 419 Physical Sciences Quad\, Irvine\, 92697\, United States
CATEGORIES:Faculty,Scientific,Staff,Students,Students, Faculty, Staff Only
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END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20240430T110000
DTEND;TZID=America/Los_Angeles:20240430T120000
DTSTAMP:20260421T170003
CREATED:20231009T221147Z
LAST-MODIFIED:20240325T155921Z
UID:10000437-1714474800-1714478400@brain.uci.edu
SUMMARY:Chioma Okeoma\, Ph.D.
DESCRIPTION:CNLM Colloquium Series \nJoin the Center for the Neurobiology of Learning and Memory (CNLM) for a virtual event featuring Dr. Chioma Okeoma\, associate professor of pathology\, microbiology\, and immunology at the New York Medical College. This event will be held virtually via Zoom. \nExtracellular condensates – do we have to worry about them?
URL:https://brain.uci.edu/event/chioma-okeoma-ph-d/
LOCATION:Virtual via Zoom\, CA
CATEGORIES:Faculty,Scientific,Staff,Students,Students, Faculty, Staff Only
ATTACH;FMTTYPE=image/jpeg:https://brain.uci.edu/wp-content/uploads/sites/49/2023/10/Okeoma_Headshot-250.jpg
ORGANIZER;CN="UCI Center for the Neurobiology of Learning and Memory":MAILTO:memory@uci.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20240503T120000
DTEND;TZID=America/Los_Angeles:20240503T131500
DTSTAMP:20260421T170003
CREATED:20240416T160932Z
LAST-MODIFIED:20240416T171250Z
UID:10000525-1714737600-1714742100@brain.uci.edu
SUMMARY:Darren Schreiber\, PhD
DESCRIPTION:Join the UCI Center for Neuropolitics for their lecture with Darren Schreiber\, PhD\, JD\, Senior Lecturer in Politics at the University of Exeterin. \nGuess Who’s Coming to Dinner in 2024? How Partisan Identity Politics is Taking Over America \nThe past twenty years have demonstrated the role of biology in our political predispositions\, with evidence from twin studies\, genetics\, and brain imaging. Recent trends have highlighted political polarization on an emotional\, identity-driven level where the other side is seens as a hated enemy. The consequences have ranged from increasing dissatisfaction with democracy to a rise in violent extremism.
URL:https://brain.uci.edu/event/darren-schreiber-phd/
LOCATION:Zoom Webinar
CATEGORIES:All,Community,Faculty,Scientific,Staff,Students
ATTACH;FMTTYPE=image/png:https://brain.uci.edu/wp-content/uploads/sites/49/2024/04/Untitled-design-21.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20240507T110000
DTEND;TZID=America/Los_Angeles:20240507T120000
DTSTAMP:20260421T170003
CREATED:20231009T221552Z
LAST-MODIFIED:20240206T183816Z
UID:10000438-1715079600-1715083200@brain.uci.edu
SUMMARY:Daeyeol Lee\, Ph.D.
DESCRIPTION:Join the Center for the Neurobiology of Learning and Memory (CNLM) for a hybrid event featuring Dr. Daeyeol Lee\, Bloomberg Distinguished Professor of neuroscience\, psychological and brain sciences at Johns Hopkins University. This event will be held in-person in the Herklotz Conference Center and virtually via Zoom. \nPlaying Games in the Brain \n \nDescription: \nSocial animals face the challenging task of predicting the actions of others. Game theory formalizes the decision making in social settings\, and reinforcement learning theories can be applied to understand the cognitive processes involved in iterative social interactions. In this talk\, I will review the neural correlates of such iterative learning in primate prefrontal cortex during simple competitive games\, such as the rock-paper-scissors\, as well as a more cognitively complex board game\, such as the 4-in-a-row. The results from these experiments demonstrate the advantage of formal games in deciphering the neurocomputational mechanisms of decision making and planning.
URL:https://brain.uci.edu/event/daeyeol-lee-ph-d/
LOCATION:CNLM Herklotz Conference Center and Virtually via Zoom
CATEGORIES:Faculty,Scientific,Staff,Students,Students, Faculty, Staff Only
ATTACH;FMTTYPE=image/jpeg:https://brain.uci.edu/wp-content/uploads/sites/49/2023/10/daeyeol.jpg
ORGANIZER;CN="UCI Center for the Neurobiology of Learning and Memory":MAILTO:memory@uci.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20240509T110000
DTEND;TZID=America/Los_Angeles:20240509T140000
DTSTAMP:20260421T170003
CREATED:20240430T193453Z
LAST-MODIFIED:20240430T221544Z
UID:10000532-1715252400-1715263200@brain.uci.edu
SUMMARY:2024 CNLM Award Ceremony
DESCRIPTION:Join the Center for the Neurobiology of Learning and Memory (CNLM) for the 2024 CNLM Awards Ceremony. \nThe CNLM offers awards to exceptional postdoctoral researchers\, graduate trainees\, undergraduates students\, faculty\, and alumni.  Student and trainee awardees will be invited to present their work in brief Elevator Pitch format to the UCI academic community and the public at our annual CNLM Awards Ceremony. \n \nFor more information\, please visit: https://cnlm.uci.edu/awards/
URL:https://brain.uci.edu/event/2024-cnlm-award-ceremony/
LOCATION:Irvine Improv\, 527 Spectrum Center Dr\, 527 Spectrum Center Dr\, 92618\, United States
CATEGORIES:All,Community,Faculty,Scientific,Staff,Students,Students, Faculty, Staff Only
ATTACH;FMTTYPE=image/png:https://brain.uci.edu/wp-content/uploads/sites/49/2024/04/For-more-information-please-visit-httpscnlm.uci_.eduawards.png
ORGANIZER;CN="UCI Center for the Neurobiology of Learning and Memory":MAILTO:memory@uci.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20240516T110000
DTEND;TZID=America/Los_Angeles:20240516T120000
DTSTAMP:20260421T170003
CREATED:20240409T211009Z
LAST-MODIFIED:20240409T213139Z
UID:10000518-1715857200-1715860800@brain.uci.edu
SUMMARY:Samantha Butler\, PhD
DESCRIPTION:“Revisiting the role(s) of netrin1 in the establishment of spinal cord circuitry.” \nThe department of Developmental and Cell Biology is hosting Dr Samantha Butler in their weekly seminar series. Dr Butler is the Eleanor I. Leslie Chair in Pioneering Brain Research; a professor in the UCLA Department of Neurobiology as well as the vice chair for Equity\, Diversity\, and Inclusion; a member of the UCLA Eli and Edythe Broad Center of Regenerative Medicine & Stem Cell Research\, the Intellectual & Developmental Disabilities Research Center\, and the David Geffen School of Medicine at UCLA.
URL:https://brain.uci.edu/event/samantha-butler-phd/
LOCATION:4201 Natural Sciences II\, Irvine\, CA 92697\, Irvine\, CA\, 92697\, United States
CATEGORIES:Faculty,Scientific,Students
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END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20240521T110000
DTEND;TZID=America/Los_Angeles:20240521T120000
DTSTAMP:20260421T170003
CREATED:20231009T211617Z
LAST-MODIFIED:20240123T184610Z
UID:10000430-1716289200-1716292800@brain.uci.edu
SUMMARY:Brad Postle\, Ph.D.
DESCRIPTION:CNLM Colloquium Series \nControlling the Contents of Visual Working Memory \nJoin the Center for the Neurobiology of Learning and Memory (CNLM) for a hybrid event featuring Dr. Brad Postle\, professor of psychology at the University of Wisconsin-Madison. This event will be held in-person in the Herklotz Conference Center and virtually via Zoom. \n \nDescription: \nTwo hallmarks of working memory are flexibility — ability to mentally juggle multiple pieces of information\, prioritizing what’s relevant for the task immediately at hand while also keeping potentially important but currently unprioritized information in an accessible state — and updateability — allowing for the rapid replacement of the no-longer-needed with the newly relevant. This talk will explore these two aspects of the control of working memory at the levels of algorithmic operation and neural implementation. Specifically\, although parsimony holds that “deprioritization” and “removal” might be accomplished via the same mechanism\, I will draw on neuroimaging (EEG and fMRI)\, computational (RNN\, RL)\, and behavioral data to argue for two distinct\, novel\, processes for controlling the contents of WM: the transformation of representational geometries as a function of priority; and the top-down hijacking of mechanisms of adaptation to accomplish active removal. This work may generalize to broader questions\, such as of how we control the moment-to-moment contents of conscious awareness\, and how we diagnose and treat disorders of thought.
URL:https://brain.uci.edu/event/brad-postle-ph-d/
LOCATION:CNLM Herklotz Conference Center and Virtually via Zoom
CATEGORIES:Faculty,Scientific,Staff,Students,Students, Faculty, Staff Only
ATTACH;FMTTYPE=image/jpeg:https://brain.uci.edu/wp-content/uploads/sites/49/2023/10/Postle_forPsychWeb250.jpg
ORGANIZER;CN="UCI Center for the Neurobiology of Learning and Memory":MAILTO:memory@uci.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20240522T090000
DTEND;TZID=America/Los_Angeles:20240522T150000
DTSTAMP:20260421T170003
CREATED:20240401T041115Z
LAST-MODIFIED:20240401T041115Z
UID:10000514-1716368400-1716390000@brain.uci.edu
SUMMARY:EpiCenter Symposium
DESCRIPTION:The 2024 EpiCenter Symposium will celebrate the 20th year of the NIH T32 program in epilepsy research. Talks will feature speakers working to solve important problems related to epilepsy in the laboratory\, the clinic and the community.
URL:https://brain.uci.edu/event/epicenter-symposium/
LOCATION:Sue Gross Auditorium\, 854 Health Sciences Rd\, Irvine\, 92617\, United States
CATEGORIES:Community,Faculty,Scientific,Staff,Students
ATTACH;FMTTYPE=image/jpeg:https://brain.uci.edu/wp-content/uploads/sites/49/2024/03/epicenter.jpg
END:VEVENT
END:VCALENDAR