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DTSTART;TZID=America/Los_Angeles:20191112T110000
DTEND;TZID=America/Los_Angeles:20191112T120000
DTSTAMP:20260419T110426
CREATED:20190910T183204Z
LAST-MODIFIED:20190910T183204Z
UID:10000084-1573556400-1573560000@brain.uci.edu
SUMMARY:Robert Hunt\, Ph.D.
DESCRIPTION:Interneurons and the control of memory precision \nInhibitory interneurons govern the sparse activation of principal cells that permits appropriate behaviors\, and they are activated during specific memory processes. Our recent work has demonstrated important roles for interneurons in disorders of brain development and injury. These studies have motivated our ongoing efforts to understand how these cells operate at the synaptic\, circuit and behavioral levels and in designing new technologies targeting specific populations of interneurons for therapy. I will discuss our recent efforts examining the role of interneurons in memory disorders and in designing cell-based therapies that enable precise manipulation of inhibitory circuits in the brain.
URL:https://brain.uci.edu/event/roberthuntcolloquium/
LOCATION:Irvine\, CA\, 92697\, United States
CATEGORIES:Faculty,Staff,Students
ATTACH;FMTTYPE=:
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BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20191114T110000
DTEND;TZID=America/Los_Angeles:20191114T120000
DTSTAMP:20260419T110426
CREATED:20191101T225407Z
LAST-MODIFIED:20191101T225407Z
UID:10000102-1573729200-1573732800@brain.uci.edu
SUMMARY:Francesco Battaglia\, Ph.D.
DESCRIPTION:Cortico-hippocampal interactions for memory\nFrancesco Battaglia\, PhD\, Donders Institute for Brain\, Cognition and Behaviour\, Radboud University Nijmegen \nMemory representations are evolving objects through the lifetime of a memory. The recording of large groups of neurons from behaving animals has been instrumental for investigating brain network dynamics supporting memory encoding consolidation and retrieval. Classically\, upon memory encoding during active behavior\, hippocampal activity is dominated by theta oscillations. During inactivity\, hippocampal neurons burst synchronously\, constituting sharp waves\, which can propagate to other structures\, theoretically supporting memory consolidation. The PFC is one prominent target. This ‘two-stage’ model has been updated by new data from high-density electrophysiological recordings in animals that shed light on how information is encoded and exchanged between hippocampus and PFC. I will present an overview of this field focusing on results from my lab on cortico-hippocampal dynamics\, including new theoretical and experimental developments.  I will show how functional connectivity reconstruction based on Maximum Entropy methods can uncover changes in the prefrontal neural network that are linked to learning\, and how these cortical functional network responds to hippocampal sharp waves.  The link between cortical functional networks and hippocampal sharp waves correlates with animal’s performance in the behavioral task. In order to better delineate this link\, we designed a novel behavioral task\, the “object-space” task\, which allows to compare episodic-like memory acquisition\, with memory acquired by accumulation across multiple episodes\, while the basic behavioral sequence is very similar and comparable across conditions.
URL:https://brain.uci.edu/event/battaglia/
LOCATION:Irvine\, CA\, 92697\, United States
CATEGORIES:Faculty,Scientific,Students, Faculty, Staff Only
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DTSTART;TZID=America/Los_Angeles:20191115T170000
DTEND;TZID=America/Los_Angeles:20191115T193000
DTSTAMP:20260419T110426
CREATED:20191030T164325Z
LAST-MODIFIED:20191030T164325Z
UID:10000097-1573837200-1573846200@brain.uci.edu
SUMMARY:Richard G. Ellenbogen\, MD\, FACS
DESCRIPTION:The 3rd Annual John A. Kusske Lecture Series \nRichard G. Ellenbogen\, MD\, FACS\nThe Myth of Equipoise\nTheodore S. Roberts Professor\nChair and Residency Program Director Department of Neurological Surgery University of Washington \nRSVP to Cindy Wang at ucineurosurgery@hs.uci.edu or 714-456-3402. Seating is limited.
URL:https://brain.uci.edu/event/ellenbogen/
LOCATION:Irvine\, CA\, 92697\, United States
CATEGORIES:Faculty,Staff,Students
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