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DTSTART;TZID=America/Los_Angeles:20220614T120000
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DTSTAMP:20260421T181448
CREATED:20220602T201944Z
LAST-MODIFIED:20220602T201944Z
UID:10000331-1655208000-1655211600@brain.uci.edu
SUMMARY:Albert La Spada\, PhD
DESCRIPTION:Deconstructing Neurodegenerative Proteinopathies: From Pathology of Neuron Demise to Therapeutic Interventon \nJoin the Department of Neurobiology and Behavior in a hybrid seminar featuring Dr. Albert La Spada. \n \nAbstract:Both rare inherited neurodegenerative disorders and common sporadic neurodegenerative diseases are caused by misfolded proteins that accumulate in neurons and glia of affected patients.  The CAG – polyglutamine (PolyQ) repeat diseases are one category of inherited neurodegenerative disorders that are caused by the expansion of a CAG triplet repeat\, resulting in a protein with an abnormally extended polyglutamine (polyQ) tract.  The repeat expansions in these diseases occur in the coding region\, and lead to the production of aggregate-prone proteins.  Of the nine CAG-PolyQ diseases\, I have been studying the disease pathogenesis of three such disorders: X-linked spinal & bulbar muscular atrophy (SBMA/Kennedy’s disease)\, Huntington’s disease\, and spinocerebellar ataxia type 7.  To determine the cellular and molecular basis of these diseases\, I have relied upon mouse models and human stem cell models\, and through these efforts\, I have uncovered a central role for transcription dysregulation\, altered proteostasis\, and bioenergetic abnormalities in the pathogenesis of these disorders.  Unbiased transcriptome analysis and directed studies of cell-type contribution have yielded crucial insights into the nature of these diseases\, and have revealed targets and pathways likely amenable to therapeutic manipulation. \nHybrid Event\nThe seminar will be live-streamed via zoom and in person.\nPlease RSVP to let us know how you will attend and receive zoom link. \nIn-Person Meeting: Interdisciplinary Science and Engineering Building (ISEB) auditorium
URL:https://brain.uci.edu/event/albert-la-spada-phd/
LOCATION:Interdisciplinary Science and Engineering Building (ISEB) and Virtually Via Zoom\, 419 Physical Sciences Quad\, Irvine\, 92697\, United States
CATEGORIES:Faculty,Scientific,Staff
ATTACH;FMTTYPE=image/jpeg:https://brain.uci.edu/wp-content/uploads/sites/49/2022/06/image.jpeg
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