BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Brain - ECPv6.15.18//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:Brain
X-ORIGINAL-URL:https://brain.uci.edu
X-WR-CALDESC:Events for Brain
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:America/Los_Angeles
BEGIN:DAYLIGHT
TZOFFSETFROM:-0800
TZOFFSETTO:-0700
TZNAME:PDT
DTSTART:20220313T100000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0700
TZOFFSETTO:-0800
TZNAME:PST
DTSTART:20221106T090000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0800
TZOFFSETTO:-0700
TZNAME:PDT
DTSTART:20230312T100000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0700
TZOFFSETTO:-0800
TZNAME:PST
DTSTART:20231105T090000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0800
TZOFFSETTO:-0700
TZNAME:PDT
DTSTART:20240310T100000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0700
TZOFFSETTO:-0800
TZNAME:PST
DTSTART:20241103T090000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230131T110000
DTEND;TZID=America/Los_Angeles:20230131T120000
DTSTAMP:20260419T004112
CREATED:20220922T151720Z
LAST-MODIFIED:20221222T024742Z
UID:10000342-1675162800-1675166400@brain.uci.edu
SUMMARY:Javier Diaz Alonso\, Ph.D.
DESCRIPTION:CNLM Colloquium UCI Spotlight Series \nChasing the AMPAR slot(s). Multiple mechanisms modulate synaptic strength. \nJoin the CNLM in a hybrid colloquium featuring Dr. Javier Diaz Alonso\, Assistant Professor of Anatomy and Neurobiology at UC Irvine. \nThis event will be held in-person in the Herklotz Conference Center and virtually via Zoom. \n \nDescription: \nLong-term potentiation (LTP) of excitatory synapses is essential for multiple forms of learning and memory formation. Pioneering work from CNLM members and others led to a model for NMDAR-dependent LTP where synaptic strengthening depends on the recruitment of AMPA receptors to the postsynapse. Despite decades of research\, the molecular mechanisms underlying the activity-dependent insertion of AMPA receptors at synapses\, and specifically which regions in the receptor complex are required for trafficking and docking\, are not fully understood. In the past few years\, we have assessed the role played by different protein domains of the AMPAR complex in these processes\, focusing on: i) the sequence diverse intracellular AMPAR C-tails\, ii) the extracellular ATDs\, which protrude into the synaptic cleft and iii) the AMPAR auxiliary proteins TARPs\, which interact with synaptic scaffolds. Our recent and ongoing work is revealing an important role for all of these 3 elements\, yet our data suggests that they play different roles in different synapses and control different AMPAR-dependent processes. I will discuss our unpublished work\, in collaboration with other CNLM labs\, dissecting novel molecular mechanisms modulating the activity-dependent synaptic accumulation and subsynaptic positioning of AMPARs to support novelty processing\, learning and memory formation.
URL:https://brain.uci.edu/event/javier-diaz-alonso-ph-d-2/
LOCATION:CNLM Herklotz Conference Center and Virtually via Zoom
CATEGORIES:Faculty,Scientific,Staff,Students
ATTACH;FMTTYPE=image/jpeg:https://brain.uci.edu/wp-content/uploads/sites/49/2021/10/Dr.-Diaz-Alonso-3x2-1-300x200-1.jpg
ORGANIZER;CN="UCI Center for the Neurobiology of Learning and Memory":MAILTO:memory@uci.edu
END:VEVENT
END:VCALENDAR