BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Brain - ECPv6.15.18//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:Brain
X-ORIGINAL-URL:https://brain.uci.edu
X-WR-CALDESC:Events for Brain
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:America/Los_Angeles
BEGIN:DAYLIGHT
TZOFFSETFROM:-0800
TZOFFSETTO:-0700
TZNAME:PDT
DTSTART:20210314T100000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0700
TZOFFSETTO:-0800
TZNAME:PST
DTSTART:20211107T090000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0800
TZOFFSETTO:-0700
TZNAME:PDT
DTSTART:20220313T100000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0700
TZOFFSETTO:-0800
TZNAME:PST
DTSTART:20221106T090000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0800
TZOFFSETTO:-0700
TZNAME:PDT
DTSTART:20230312T100000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0700
TZOFFSETTO:-0800
TZNAME:PST
DTSTART:20231105T090000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20220301T100000
DTEND;TZID=America/Los_Angeles:20220301T110000
DTSTAMP:20260421T015614
CREATED:20220222T165026Z
LAST-MODIFIED:20220222T165026Z
UID:10000301-1646128800-1646132400@brain.uci.edu
SUMMARY:CNCM Seminar: Dr. Edward Zagha
DESCRIPTION:Neural mechanisms of target stimulus selection and distractor stimulus suppression \nJoin the UCI Center for Neural Circuit Mapping in a Hybrid (Virtual and In-Person) Seminar featuring Edward Zagha\, MD\, PhD from UC Riverside. \nThose who wish to attend in person will receive details upon registration. \nAbstract: \n Goal-directed behavior requires the ability to respond to task-relevant target stimuli (selection) while inhibiting responses to extraneous distractor stimuli (suppression). To better understand the neural mechanisms underlying these processes\, we trained mice in an operant whisker detection task in which they learned to respond to brief stimuli in one whisker field (target) and ignore identical stimuli in the opposite whisker field (distractor). We subsequently performed a range of neuronal recording and perturbation experiments in expert mice while they were performing this selective detection task. In this talk\, I will present data from three studies related to the differential neural processing of target and distractor signals. First\, I will demonstrate the robust attenuation of distractor-evoked responses downstream of primary somatosensory cortex (Aruljothi et al.\, 2020). Second\, I will show that frontal cortex and dorsolateral striatum have highly similar task-related neuronal representations\, and yet make drastically different functional contributions to target selection and distractor suppression. Third\, I will provide evidence for a novel mechanism by which top-down signals from frontal cortex to sensory cortex contribute to target-distractor selectivity. Overall\, these studies reveal cortical and subcortical mechanisms by which sensory signals are appropriately routed according to goal direction (Zagha 2020).
URL:https://brain.uci.edu/event/cncm-seminar-dr-edward-zagha/
LOCATION:Virtual Event
CATEGORIES:Scientific,Staff,Students
ATTACH;FMTTYPE=image/jpeg:https://brain.uci.edu/wp-content/uploads/sites/49/2022/02/image-1.jpeg
END:VEVENT
END:VCALENDAR