BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Brain - ECPv6.15.18//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:Brain
X-ORIGINAL-URL:https://brain.uci.edu
X-WR-CALDESC:Events for Brain
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:America/Los_Angeles
BEGIN:DAYLIGHT
TZOFFSETFROM:-0800
TZOFFSETTO:-0700
TZNAME:PDT
DTSTART:20220313T100000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0700
TZOFFSETTO:-0800
TZNAME:PST
DTSTART:20221106T090000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0800
TZOFFSETTO:-0700
TZNAME:PDT
DTSTART:20230312T100000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0700
TZOFFSETTO:-0800
TZNAME:PST
DTSTART:20231105T090000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0800
TZOFFSETTO:-0700
TZNAME:PDT
DTSTART:20240310T100000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0700
TZOFFSETTO:-0800
TZNAME:PST
DTSTART:20241103T090000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20230214T110000
DTEND;TZID=America/Los_Angeles:20230214T120000
DTSTAMP:20260421T151145
CREATED:20220922T151507Z
LAST-MODIFIED:20221129T194501Z
UID:10000341-1676372400-1676376000@brain.uci.edu
SUMMARY:Kei Igarashi\, Ph.D.
DESCRIPTION:Circuit mechanisms of associative memory in health and Alzheimer’s disease \nCNLM Colloquium UCI Spotlight Series \nJoin the CNLM in a hybrid colloquium featuring Dr. Kei Igarashi\, Associate Professor of Anatomy and Neurobiology at UC Irvine. \nDescription:\n\nMounting evidence shows that dopamine in the striatum is critically involved in reward-based reinforcement learning. However\, it remains unclear how dopamine reward signals influence the entorhinal-hippocampal circuit\, another brain network critical for learning and memory. Using in vivo optogenetic and electrophysiological approaches\, we recently found that dopamine signals from the ventral tegmental area control encoding of cue-reward association rules in the lateral entorhinal cortex (LEC) (Lee et al.\, Nature\, 2021). Our results suggest that LEC represent a cognitive map of abstract task rules\, and LEC dopamine facilitates the incorporation of new memories into this map. I would like to discuss how we can unify the roles of two central\, but previously independent\, players in learning – dopamine and the entorhinal-hippocampal circuit – in future studies. In the second part of the talk\, I will share our results on how neuronal activities in the entorhinal-hippocampal memory circuit are lost in a mouse model of Alzheimer’s disease (Jun et al.\, Neuron\, 2020)\, and discuss how the systems neuroscience approach can contribute to the understanding of Alzheimer’s disease pathogenesis. \nThis event will be held in-person in the Herklotz Conference Center and virtually via Zoom.
URL:https://brain.uci.edu/event/kei-igarashi-ph-d/
LOCATION:CNLM Herklotz Conference Center and Virtually via Zoom
CATEGORIES:Faculty,Scientific,Staff,Students
ATTACH;FMTTYPE=image/jpeg:https://brain.uci.edu/wp-content/uploads/sites/49/2022/09/image-1.jpeg
ORGANIZER;CN="UCI Center for the Neurobiology of Learning and Memory":MAILTO:memory@uci.edu
END:VEVENT
END:VCALENDAR