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DTSTART;TZID=America/Los_Angeles:20230328T110000
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DTSTAMP:20260421T152906
CREATED:20220922T152646Z
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UID:10000346-1680001200-1680004800@brain.uci.edu
SUMMARY:Kevin T. Beier\, Ph.D.
DESCRIPTION:CNLM Colloquium UCI Spotlight Series \nJoin the CNLM in a hybrid colloquium featuring Dr. Kevin T. Beier\, Assistant Professor of Physiology and Biophysics at UC Irvine. \nMolecular mechanisms of memory stability and the molecular and circuit determinants of cocaine addiction \n  \nDescription: \nI will speak on two separate projects in our lab. First\, we have uncovered the molecular mechanism by which administration of the Zeta Inhibitory Peptide (ZIP) causes memory loss. While it was previously believed that ZIP administration perturbs memory stability through disruption of constitutive kinase activity\, recent studies have cast doubt on this hypothesis. However\, ZIP’s effects on memory stability are robust\, raising the question of what the actual mechanism is by which ZIP exerts its function. We have identified the basic molecular and pathways engaged by ZIP\, and use this information to identify an inhibitor that\, together with ZIP\, enables bidirectional modulation of synaptic plasticity. Second\, we are exploring the biological factors that influence the behavioral response to the administration of drugs of abuse. Some individuals that take drugs of abuse are susceptible to developing dependence\, while others are resilient. The fundamental source of this variation is not understood. We will discuss our work implicating circuit- and molecular-level changes in the globus pallidus that facilitate individual differences in response to cocaine administration\, and share the identification of a novel small molecule compound\, isolated from rosemary\, that blunts drug reward and volitional intake. \nThis event will be held in-person in the Herklotz Conference Center and virtually via Zoom.
URL:https://brain.uci.edu/event/kevin-t-beier-ph-d/
LOCATION:CNLM Herklotz Conference Center and Virtually via Zoom
CATEGORIES:Faculty,Scientific,Staff,Students
ATTACH;FMTTYPE=image/jpeg:https://brain.uci.edu/wp-content/uploads/sites/49/2022/09/image-3.jpeg
ORGANIZER;CN="UCI Center for the Neurobiology of Learning and Memory":MAILTO:memory@uci.edu
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