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X-WR-CALDESC:Events for Brain
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DTSTART;TZID=America/Los_Angeles:20230425T110000
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DTSTAMP:20260421T085216
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UID:10000394-1682420400-1682424000@brain.uci.edu
SUMMARY:James L. McGaugh Distinguished Seminar Series with Dr. Elizabeth Gould
DESCRIPTION:Sex differences in early life adversity effects on hippocampal plasticity\n\nDr. Elizabeth Gould\nDepartment of Psychology\nPrinceton Neuroscience Institute \nHybrid Event\nThis seminar will be live-streamed via Zoom and In-Person. \nIn-Person: \nHerklotz Conference Room\nCenter for the Neurobiology of Learning and Memory\n300 Qureshey Research Lab\nRSVP for Zoom Link\nAbstract: \nEarly life adversity (ELA) increases the likelihood of neuropsychiatric disease\, including anxiety and mood disorders. Sex differences exist in the incidence of these conditions\, and types of ELA are known to produce differential vulnerabilities. My talk will focus on our efforts to use two different mouse models of ELA to explore plasticity mechanisms underlying sex differences in behavioral outcomes. We found that an ELA model of neglect\, but not one of abuse\, increases ventral hippocampal-dependent avoidance behavior in both males and females. Overall\, females exhibit greater avoidance than males\, with further increases observed after ELA only during the diestrus phase of the estrous cycle. Increases in avoidance in ELA females during diestrus are likely related to diminished conversion of progesterone to the neurosteroid allopregnanolone in the ventral hippocampus. These changes are coincident with increased power of theta oscillations and altered composition of perineuronal nets\, extracellular matrix structures known to limit plasticity\, around parvalbumin-positive inhibitory interneurons. Sex differences are also observed in response to two types of ELA on social recognition\, another function that involves the hippocampus. Males\, but not females\, show deficits in social memory after exposure to ELA models of neglect or abuse. Despite these similarities within males\, underlying mechanisms differ depending on the type of ELA experienced. ELA-neglect reduced the number of stem cells and adult-born neurons in the hippocampus. This effect seems causally linked to social recognition deficits because chemogenetic stimulation of adult-born neurons in ELA-neglect mice restores this function.  By contrast\, ELA-abuse does not affect the number of adult-born neurons but increases perineuronal nets in the CA2 region. Collectively\, these findings highlight how sex and ELA type are important determinants of hippocampal plasticity and behavioral outcomes. \nFor more information please check out: https://gouldlab.princeton.edu/
URL:https://brain.uci.edu/event/james-l-mcgaugh-distinguished-seminar-series-with-dr-elizabeth-gould/
LOCATION:CNLM Herklotz Conference Center\, Irvine\, CA\, 92697\, United States
CATEGORIES:Community,Scientific,Staff,Students
ATTACH;FMTTYPE=image/jpeg:https://brain.uci.edu/wp-content/uploads/sites/49/2023/03/unnamed-1-1.jpg
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DTSTART;TZID=America/Los_Angeles:20230426T080000
DTEND;TZID=America/Los_Angeles:20230430T170000
DTSTAMP:20260421T085216
CREATED:20230329T164104Z
LAST-MODIFIED:20230329T164104Z
UID:10000398-1682496000-1682874000@brain.uci.edu
SUMMARY:LEARNMEM2023
DESCRIPTION:Join the Center for the Neurobiology of Learning and Memory for the 2023 International Conference on Learning and Memory (LEARNMEM™2023) on April 26-30\, 2023 in Huntington Beach\, CA. The Conference will be held in celebration of the 40th Anniversary of the Center for the Neurobiology of Learning and Memory (CNLM). \nLEARNMEM™2023 will feature keynote talks by distinguished speakers\, scientific symposia\, lightning talks\, open papers\, poster sessions as well as professional development and networking opportunities. \nThe conference will have a substantial impact on the field by accelerating the pace of team science and providing a unique networking opportunity for the next generation of leaders in neuroscience.
URL:https://brain.uci.edu/event/learnmem2023/
LOCATION:Waterfront Beach Resort\, 21100 Pacific Coast Highway\, Huntington Beach\, CA\, 92648\, United States
CATEGORIES:Faculty,Scientific,Staff,Students,Students, Faculty, Staff Only
ATTACH;FMTTYPE=image/jpeg:https://brain.uci.edu/wp-content/uploads/sites/49/2023/03/LearnMem2023RegistrationBanner-01-1536x831-1.jpg
ORGANIZER;CN="UCI Center for the Neurobiology of Learning and Memory":MAILTO:memory@uci.edu
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