BEGIN:VCALENDAR VERSION:2.0 PRODID:-//Brain - ECPv6.15.18//NONSGML v1.0//EN CALSCALE:GREGORIAN METHOD:PUBLISH X-WR-CALNAME:Brain X-ORIGINAL-URL:https://brain.uci.edu X-WR-CALDESC:Events for Brain REFRESH-INTERVAL;VALUE=DURATION:PT1H X-Robots-Tag:noindex X-PUBLISHED-TTL:PT1H BEGIN:VTIMEZONE TZID:America/Los_Angeles BEGIN:DAYLIGHT TZOFFSETFROM:-0800 TZOFFSETTO:-0700 TZNAME:PDT DTSTART:20230312T100000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:-0700 TZOFFSETTO:-0800 TZNAME:PST DTSTART:20231105T090000 END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:-0800 TZOFFSETTO:-0700 TZNAME:PDT DTSTART:20240310T100000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:-0700 TZOFFSETTO:-0800 TZNAME:PST DTSTART:20241103T090000 END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:-0800 TZOFFSETTO:-0700 TZNAME:PDT DTSTART:20250309T100000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:-0700 TZOFFSETTO:-0800 TZNAME:PST DTSTART:20251102T090000 END:STANDARD END:VTIMEZONE BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20241119T140000 DTEND;TZID=America/Los_Angeles:20241119T153000 DTSTAMP:20260419T003943 CREATED:20241104T223119Z LAST-MODIFIED:20241105T234808Z UID:10000626-1732024800-1732030200@brain.uci.edu SUMMARY:James Antony\, PhD DESCRIPTION:The UC Irvine Department of Neurobiology and Behavior will host guest speaker Dr. James Antony\, Assistant Professor at California Polytechnic State University. \nMaking memories last: Factors that promote memory persistence \nHow do memories persist? In this talk\, I will investigate various factors that promote long-term memory. First\, I will show how moment-to-moment predictions made during perception – and errors in those predictions (surprises) – affect memory in laboratory and real-world settings. I have found that surprise affects neural responses and enhances memory for events that unfold on a variety of timescales\, from short (seconds) to long (hours to months). Second\, I will discuss how error within a computational model of the hippocampus can be used to explain the well-known benefits of distributing learning over time. And finally\, I will demonstrate how relationships among stimuli at encoding allow one to create well-fortified\, integrated memories that last. Cumulatively\, these findings significantly contribute to understanding memory persistence\, and they could aid in developing methods for improving learning in educational settings and in populations suffering from memory deficits. URL:https://brain.uci.edu/event/james-antony-phd/ LOCATION:CNLM Herklotz Conference Center and Virtually via Zoom CATEGORIES:Scientific,Staff,Students,Students, Faculty, Staff Only ATTACH;FMTTYPE=image/png:https://brain.uci.edu/wp-content/uploads/sites/49/2024/11/Untitled-design.png END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20241119T110000 DTEND;TZID=America/Los_Angeles:20241119T120000 DTSTAMP:20260419T003943 CREATED:20240925T223533Z LAST-MODIFIED:20240925T223718Z UID:10000593-1732014000-1732017600@brain.uci.edu SUMMARY:Katalin Gothard\, MD\, Ph.D. DESCRIPTION:The James L. McGaugh Distinguished Seminar will host guest speaker Dr. Katalin Gothard\, Professor of Physiology\, Neurology\, and Neuroscience\, from The University of Arizona \n“A context-dependent switch from sensing to feeling in the primate amygdala” \nTactile signals elicited in the periphery by social and affective touch acquire emotional significance in the brain. As the amygdala processes the valence of all sensory stimuli\, we predicted that the positive valence of grooming would strongly activate the monkey amygdala. To test this hypothesis\, we compared neural activity in the amygdala and the primary somatosensory cortex in response to social grooming and gentle airflow delivered to the same areas of the skin. Neurons in the somatosensory cortex responded to both types of tactile stimuli. In the amygdala\, however\, neurons did not respond to individual grooming sweeps even though grooming elicited autonomic states indicative of positive affect. Instead of responses to individual touch stimuli\, a large proportion of neurons showed enhanced or suppressed baseline firing rates that persisted throughout a grooming bout. These changes were attributed to social context because the presence of the groomer alone could account for increases or decreases in baseline firing rates. It appears\, therefore\, that during grooming\, the amygdala stops responding to external inputs on a short time scale but remains responsive to social context\, and the associated affective states\, on longer time scales. \n  URL:https://brain.uci.edu/event/katalin-gothard-md-ph-d/ LOCATION:CNLM Herklotz Conference Center\, Irvine\, CA\, 92697\, United States CATEGORIES:Faculty,Scientific,Staff,Students,Students, Faculty, Staff Only ATTACH;FMTTYPE=image/png:https://brain.uci.edu/wp-content/uploads/sites/49/2024/09/Jeffrey-Krichmar-Ph.D.-10.png END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20241119T100000 DTEND;TZID=America/Los_Angeles:20241119T110000 DTSTAMP:20260419T003943 CREATED:20240205T212900Z LAST-MODIFIED:20241030T181737Z UID:10000485-1732010400-1732014000@brain.uci.edu SUMMARY:Li Gan\, PhD DESCRIPTION:The Center for Neural Circuit Mapping will host guest speaker Dr. Li Gan\, Director of the Helen and Robert Appel Alzheimer’s Disease Research Institute at Cornell University. \nInnate immunity and neurodegeneration: challenges and opportunities \nAs the resident immune cells in the brain\, microglia serve as liaisons between the immune system and CNS and are strategically located to participate in the onset and progression of CNS inflammatory responses in neurodegenerative diseases. Identifying protective and toxic pathways in microglia in neurodegeneration could lead to new therapeutic targets. Our laboratory research has identified pivotal pathways in microglia that play significant roles in neurodegenerative diseases. We have explored their contribution to inflammatory responses\, including NF-kB\, Akt\, and cGAS-STING-IFN-I in progression of disease pathology and cognitive resilience. We have extended our novel mechanistic insights to small molecule microglial modulators that specifically target the toxic aspects of microglia responses in neurodegeneration. Future endeavors will focus on how microglia interact with other brain cells in the CNS\, with the goal of establishing new\, effective microglia-targeted therapeutic strategies. URL:https://brain.uci.edu/event/li-gan-phd/ LOCATION:Interdisciplinary Science and Engineering Building (ISEB) 1200\, Irvine\, CA\, 92697\, United States ATTACH;FMTTYPE=image/png:https://brain.uci.edu/wp-content/uploads/sites/49/2024/02/Untitled-design-7.png END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20241118T080000 DTEND;TZID=America/Los_Angeles:20241118T180000 DTSTAMP:20260419T003943 CREATED:20241014T174712Z LAST-MODIFIED:20241014T233451Z UID:10000605-1731916800-1731952800@brain.uci.edu SUMMARY:Psychedelics Through the Lens of Science\, Treatment\, and Policy DESCRIPTION:Please join UC Irvine’s Center for Addiction Neuroscience (UCI CAN) for an all-day symposium entitled: “Psychedelics Through the Lens of Science\, Treatment\, and Policy“\, to be held on Monday November 18 at Herklotz Auditorium of the UCI Center for Neurobiology of Learning and Memory. \nWe will hear perspectives of academic researchers\, psychiatrists\, and policymakers from across North America\, all discussing aspects of the recent resurgence of interest in psychedelic molecules\, many of which have been known for millennia by indigenous cultures for their consciousness-altering and medicinal properties. \nJoin us for a wide-ranging discussion of psychedelic neuroscience\, psychiatry\, and policy with experts from: University of Calgary; UC Berkeley; UC Irvine; the National Institute on Drug Abuse; and the US Food & Drug Administration. \nPre-registration is required\, it is free\, and it comes with breakfast\, lunch and reception\, as well as brand new ICAN swag! \nCapacity is limited for this in-person event\, so don’t hesitate: REGISTER TODAY! \n2024 Psychedelics Symposium Registration URL:https://brain.uci.edu/event/psychedelics-through-the-lens-of-science-treatment-and-policy/ LOCATION:CNLM Herklotz Conference Center\, Irvine\, CA\, 92697\, United States ATTACH;FMTTYPE=image/png:https://brain.uci.edu/wp-content/uploads/sites/49/2024/10/Untitled-design-25.png ORGANIZER;CN="UC Irvine Center for Addiction Neuroscience":MAILTO:shahrdad@uci.edu END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20241113T120000 DTEND;TZID=America/Los_Angeles:20241113T130000 DTSTAMP:20260419T003943 CREATED:20241112T191145Z LAST-MODIFIED:20241112T191145Z UID:10000631-1731499200-1731502800@brain.uci.edu SUMMARY:Sara Mednick\, Ph.D DESCRIPTION:The Department of Cognitive Sciences will host guest speaker Dr. Sara Mednick\, professor at the University of California\, Irvine \nBrain mechanisms of sleep that sculpt our memories \nSleep is a daily period of deep rest that is important for proper functioning of the brain and body. Studies show that adequate sleep supports enhanced cognitive functions\, including memory\, creativity\, attention\, mood\, and promotes healthy bodily functions\, including physical stamina\, metabolism and cardiac activity. Recent findings have demonstrated that sleep may be especially important for the transformation of new experiences into long-term memories\, a process known as memory consolidation. My UC Irvine Sleep and Cognition (SaC) lab is interested in identifying basic neural mechanisms that are critical for memory consolidation so that we can 1) understand the function of sleep\, 2) reveal the processes of memory\, 3) and develop interventions that boost sleep-dependent cognitive processes. In my talk\, I will introduce the building blocks of sleep and their relation to cognitive processes\, as well suggest that cognitive changes that occur across the lifespan may be mediated by changes in sleep. I hope to illustrate a dynamic relationship that exists between waking experiences and sleeping brain that facilitates the maintenance and enhancement of our cognitive health. URL:https://brain.uci.edu/event/sara-mednick-ph-d/ LOCATION:Social and Behavioral Sciences Gateway (SBSG) 1517\, 214 Pereira Dr\, Irvine\, CA\, 92617 ATTACH;FMTTYPE=image/png:https://brain.uci.edu/wp-content/uploads/sites/49/2024/11/Untitled-design-7.png END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20241113T090000 DTEND;TZID=America/Los_Angeles:20241113T100000 DTSTAMP:20260419T003943 CREATED:20241029T184458Z LAST-MODIFIED:20241029T190431Z UID:10000612-1731488400-1731492000@brain.uci.edu SUMMARY:Greg Gage\, Ph.D. DESCRIPTION:The Center for the Neurobiology of Learning & Memory (CNLM) will host guest speaker Dr. Greg Gage\, CEO and Co-Founder of Backyard Brains\, for their CONNECT Series. \nEngaging Curiosity Through Hands-on Neuroscience \nThis talk will explore how to actively engage individuals in neuroscience before they fully grasp the underlying concepts\, focusing on approaches to hands-on learning and community involvement. I will discuss Backyard Brains’ experience creating low-cost\, open-source neuroscience tools that make neuroscience education accessible to students and the general public. Through live demonstrations and case studies\, we’ll examine how these tools can spark curiosity\, broaden participation\, and support underrepresented groups in STEM\, with a focus on fostering a hands-on approach before conceptual understanding is fully established. URL:https://brain.uci.edu/event/greg-gage-ph-d/ LOCATION:Virtual via Zoom\, CA ATTACH;FMTTYPE=image/png:https://brain.uci.edu/wp-content/uploads/sites/49/2024/10/Untitled-design-38.png ORGANIZER;CN="UC Irvine Center for the Neurobiology of Learning &%3B Memory":MAILTO:memory@uci.edu END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20241112T110000 DTEND;TZID=America/Los_Angeles:20241112T120000 DTSTAMP:20260419T003943 CREATED:20240924T171223Z LAST-MODIFIED:20241009T174711Z UID:10000584-1731409200-1731412800@brain.uci.edu SUMMARY:J. Zoe Klemfuss\, Ph.D. DESCRIPTION:  \n \nJoin the Center for the Neurobiology of Learning and Memory (CNLM) for a hybrid event featuring Dr. J. Zoe Klemfuss\, Associate Professor of Psychological Sciences at the University of California\, Irvine. \nThis event will be held in-person in the Herklotz Conference Center and virtually via Zoom. \n \nChildren’s memory reports in legal contexts \nMillions of US children are centrally involved in legal investigations each year. They may be questioned as suspected victims or witnesses or in other impactful legal proceedings like custody determinations. As one chilling example\, over 3 million children are the subjects of child protective services disposition due to suspected maltreatment annually. In some of the most heinous crimes against children such as child sexual abuse\, children’s statements may be the only available evidence. These crimes rarely have other witnesses and because disclosure is routinely delayed\, physical evidence is rare as well. My colleagues and I have been examining ways we can help children to give accurate and detailed memory reports of their legally-relevant experiences. In this talk\, I will focus on how we’ve been considering child\, interviewer\, and contextual factors as we examine 1) children’s reports of event time and sequence and 2) interviewer-child rapport and support\, and their implications for children’s legal statements. URL:https://brain.uci.edu/event/j-zoe-klemfuss-ph-d/ LOCATION:Hybrid Event (This event will be held virtually via Zoom and In-Person in the Herkltoz Conference Room)\, 300 Qureshey Research Lab Irvine\, Irvine\, CA\, 92697\, United States CATEGORIES:Faculty,Scientific,Staff,Students,Students, Faculty, Staff Only ATTACH;FMTTYPE=image/png:https://brain.uci.edu/wp-content/uploads/sites/49/2024/09/Jeffrey-Krichmar-Ph.D.-1.png ORGANIZER;CN="UCI Center for the Neurobiology of Learning and Memory":MAILTO:memory@uci.edu END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20241112T100000 DTEND;TZID=America/Los_Angeles:20241112T110000 DTSTAMP:20260419T003943 CREATED:20240205T211704Z LAST-MODIFIED:20241030T181510Z UID:10000484-1731405600-1731409200@brain.uci.edu SUMMARY:Mark Wagner\, PhD DESCRIPTION:The Center for Neural Circuit Mapping will host guest speaker Dr. Mark Wagner\, Stadtman Investigator at NIH/NINDS. \nCerebellar computations across motor and cognitive behaviors \nThe cerebellum contains most of the brain’s neurons and interconnects with the entire neocortex\, forming a basic neuroanatomical motif. With evolution\, the cerebellum expanded by orders of magnitude but mainly by replicating the same crystalline microcircuit. In humans\, movement\, learning\, attention\, working memory\, and language all engage cerebellar networks. Is there a single “cerebellar computation” useful for all behaviors\, or do new dynamics emerge from higher brain function? We aim to understand the basic computations implemented in cerebellar circuits\, their broad utility across the neocortex\, and how they flexibly contribute to many disparate behaviors. Via recordings from cerebellar granule cells in animals executing rewarded actions\, we showed that numerous granule cells anticipated reward delivery (Wagner et al Nature 2017). By developing simultaneous neocortex-cerebellum imaging\, we found that characteristically neocortical neural activity develops in tandem with similar cerebellar activity patterns during skill learning (Wagner et al Cell 2019). We also broadened understanding of cerebellar climbing fibers\, demonstrating that they can become increasingly synchronized during skilled actions as animals gain expertise (Wagner et al Cell 2021). Recently\, via simultaneous imaging of cerebellar granule cells and climbing fibers\, we found that seconds-long granule cell neural ramps enable the cerebellum to learn to track elapsed time until an expected rewarding outcome (Garcia-Garcia et al Neuron 2024). We are working to determine how: neocortical information is transformed into the cerebellum; cerebellar computation generalizes across behavioral contexts and reward modalities; and the cerebellum routes its output across many downstream circuits throughout the brain URL:https://brain.uci.edu/event/mark-wagner-phd/ LOCATION:Interdisciplinary Science and Engineering Building (ISEB) and Virtually Via Zoom\, 419 Physical Sciences Quad\, Irvine\, 92697\, United States ATTACH;FMTTYPE=image/png:https://brain.uci.edu/wp-content/uploads/sites/49/2024/02/Untitled-design-33.png END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20241108T140000 DTEND;TZID=America/Los_Angeles:20241108T150000 DTSTAMP:20260419T003943 CREATED:20241104T185342Z LAST-MODIFIED:20241104T185536Z UID:10000624-1731074400-1731078000@brain.uci.edu SUMMARY:Anthony Wagner\, PhD DESCRIPTION:The Medical Scientist Training Program will host Dr. Anthony Wagner\, world-renowned professor from Stanford University recognized for his groundbreaking work on the mechanisms of cognitive control\, episodic memory\, and the interplay between these processes. \nMechanisms of Memory Variability in Human Aging URL:https://brain.uci.edu/event/anthony-wagner-phd/ LOCATION:Plumwood House Room 166\, 1003 Health Sciences Rd\, Irvine\, CA 92617\, Irvine\, CA\, 92697-3800\, United States ATTACH;FMTTYPE=image/png:https://brain.uci.edu/wp-content/uploads/sites/49/2024/11/Untitled-design-51.png END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20241106T120000 DTEND;TZID=America/Los_Angeles:20241106T130000 DTSTAMP:20260419T003943 CREATED:20241104T190722Z LAST-MODIFIED:20241105T194913Z UID:10000625-1730894400-1730898000@brain.uci.edu SUMMARY:Ian Ballard\, Ph.D. DESCRIPTION:The Department of Cognitive Sciences will host Dr. Ian Ballard\, Assistant Professor of Psychology from the University of California\, Riverside. \nHow learning sculpts goal-directed behavior \nGoal-directed behavior requires the flexibility to update behavior in response to changing environmental contingencies. The neural systems supporting goal-directed behavior are often characterized as competing against a subcortical habit system. My research identifies cooperative interactions between these systems that support flexible decision-making. I will present a series of studies that draw on fMRI and PET neuroimaging\, computational modeling\, pharmacological probes in healthy human subjects\, and collaborative research using neural recordings in nonhuman primates. The findings show that reward learning in the striatum facilitates the selection of beneficial goals\, enabling context-dependent behavior. Furthermore\, my findings show how the striatum enables flexibility by translating negative feedback into behavioral change. This research details how the brain’s phylogenetically ancient learning mechanisms powerfully shape high-order cognition. URL:https://brain.uci.edu/event/ian-ballard-ph-d/ LOCATION:Social and Behavioral Sciences Gateway (SBSG) 1517\, 214 Pereira Dr\, Irvine\, CA\, 92617 ATTACH;FMTTYPE=image/png:https://brain.uci.edu/wp-content/uploads/sites/49/2024/11/Untitled-design-53.png END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20241105T110000 DTEND;TZID=America/Los_Angeles:20241105T120000 DTSTAMP:20260419T003943 CREATED:20240924T165621Z LAST-MODIFIED:20241009T174633Z UID:10000583-1730804400-1730808000@brain.uci.edu SUMMARY:Jeffrey Krichmar\, Ph.D. DESCRIPTION:Join the Center for the Neurobiology of Learning and Memory (CNLM) for a hybrid event featuring Dr. Jeffrey Krichmar\, Professor of Cognitive Sciences at the University of California\, Irvine. \nThis event will be held in-person in the Herklotz Conference Center and virtually via Zoom. \n \nBiologically inspired robot navigation \nWe take inspiration from recent neurophysiological findings to create a flexible navigation system for mobile robots.  In the first part of my talk\, I will present a neuromorphic path planning algorithm inspired by place cell behavior and experience-dependent plasticity. Our navigation system utilizes a spiking neural network wavefront planner and E-prop learning to concurrently map and plan paths in large\, complex environments. We incorporate a novel method for mapping which\, when combined with the spiking wavefront planner\, allows for adaptive planning by selectively considering combining costs. The learning is continuous and does not require retraining due to changes in the environment. The system is tested on a mobile robot platform in an outdoor environment with obstacles and varying terrain.  On real and simulated paths\, our system outperforms state-of-the-art robot path planners. The spiking wavefront planner is compatible with neuromorphic hardware and could be used for applications requiring low size weight and power. In the second part of my talk\, I will discuss how we seamlessly move between global perspectives and first-person perspectives and why this is important for navigation\, memory formation\, and other cognitive tasks. To understand how a neural system might carry out these computations\, we used variational autoencoders (VAEs) to reconstruct first-person perspectives from global map perspectives\, and vice versa. Many latent variables in our model had similar responses to those seen in neuron recordings\, including place cells\, head direction tuning\, and encoding distance to objects. These results could advance our understanding of how brain regions support viewpoint linkages and transformations. Currently\, we are combining these two modeling approaches into a unified biologically inspired navigation system that can handle dynamic environments. URL:https://brain.uci.edu/event/jeffrey-krichmar-ph-d/ LOCATION:Hybrid Event (This event will be held virtually via Zoom and In-Person in the Herkltoz Conference Room)\, 300 Qureshey Research Lab Irvine\, Irvine\, CA\, 92697\, United States CATEGORIES:Faculty,Scientific,Staff,Students,Students, Faculty, Staff Only ATTACH;FMTTYPE=image/png:https://brain.uci.edu/wp-content/uploads/sites/49/2024/09/Jeffrey-Krichmar-Ph.D.png ORGANIZER;CN="UCI Center for the Neurobiology of Learning and Memory":MAILTO:memory@uci.edu END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20241030T120000 DTEND;TZID=America/Los_Angeles:20241030T130000 DTSTAMP:20260419T003943 CREATED:20241029T174124Z LAST-MODIFIED:20241029T184156Z UID:10000611-1730289600-1730293200@brain.uci.edu SUMMARY:Manuella Oliveira Yassa\, Ph.D. & Caroline Montojo\, Ph.D. DESCRIPTION:The Center for the Neurobiology of Learning & Memory (CNLM) will host guest speakers Dr. Manuella Oliveira Yassa\, Director of Outreach and Education at the CNLM\, and Dr. Caroline Montojo\, President & CEO of the Dana Foundation. \nJoin us to learn more about the CONNECT series. This session will include an opportunity to network. URL:https://brain.uci.edu/event/manuella-oliveira-yassa-ph-d-caroline-montojo-ph-d/ LOCATION:Virtual via Zoom\, CA ATTACH;FMTTYPE=image/png:https://brain.uci.edu/wp-content/uploads/sites/49/2024/10/Untitled-design-37.png ORGANIZER;CN="UC Irvine Center for the Neurobiology of Learning &%3B Memory":MAILTO:memory@uci.edu END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20241029T100000 DTEND;TZID=America/Los_Angeles:20241029T110000 DTSTAMP:20260419T003943 CREATED:20241007T214557Z LAST-MODIFIED:20241007T214557Z UID:10000600-1730196000-1730199600@brain.uci.edu SUMMARY:Yang Yang\, PhD DESCRIPTION:UCI Epilepsy Research Center will host guest speaker Dr. Yang Yang\, Jack and Barbara McCoy Associate Professor from Purdue University\, for their EpiCenter Seminar. \n“SCN2A related autism and epilepsy: from mouse and hiPSC models to genetic medicine” URL:https://brain.uci.edu/event/yang-yang-phd/ LOCATION:Plumwood House\, 1003 Health Sciences Rd\, Irvine\, CA 92617\, Irvine\, CA\, 92697\, United States CATEGORIES:Faculty,Scientific,Staff,Students, Faculty, Staff Only ATTACH;FMTTYPE=image/jpeg:https://brain.uci.edu/wp-content/uploads/sites/49/2024/10/thumbnail_Yang-profile-photo-F-e1728337550531.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20241025T100000 DTEND;TZID=America/Los_Angeles:20241025T140000 DTSTAMP:20260419T003943 CREATED:20240724T190829Z LAST-MODIFIED:20240927T164849Z UID:10000555-1729850400-1729864800@brain.uci.edu SUMMARY:Perspectives on Political Violence DESCRIPTION:The Symposium of the UCI Center for Neuropolitics will address political violence in all its complexities. The Symposium will use the tools of neuroscience\, political science\, history and psychology to comprehensively analyze the disturbing development and potential emergence in American life. The Symposium includes the 2024 Jerrold Post Lecture on Neuropolitics\, to be given by Ruth Ben-Ghiat. URL:https://brain.uci.edu/event/uci-center-for-neuropolitics-lecture-series/ LOCATION:Virtual Event CATEGORIES:All ATTACH;FMTTYPE=image/jpeg:https://brain.uci.edu/wp-content/uploads/sites/49/2024/07/unnamed-17.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20241024T103000 DTEND;TZID=America/Los_Angeles:20241024T113000 DTSTAMP:20260419T003943 CREATED:20241018T174124Z LAST-MODIFIED:20241018T174350Z UID:10000607-1729765800-1729769400@brain.uci.edu SUMMARY:Yannick Fotio\, PharmD\, Ph.D. DESCRIPTION:The Department of Anatomy & Neurobiology will host Yannick Fotio\, PharmD\, Ph.D. a postdoctoral fellow in Dr. Piomelli’s lab from the University of California\, Irvine. \nMetabolic reprogramming drives pain chronification after tissue damage URL:https://brain.uci.edu/event/yannick-fotio-pharmd-ph-d/ LOCATION:Plumwood House Room 166\, 1003 Health Sciences Rd\, Irvine\, CA 92617\, Irvine\, CA\, 92697-3800\, United States ATTACH;FMTTYPE=image/jpeg:https://brain.uci.edu/wp-content/uploads/sites/49/2024/10/Anatomy_Seminar_Social_Ad_1200x675_Template.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20241023T160000 DTEND;TZID=America/Los_Angeles:20241023T180000 DTSTAMP:20260419T003943 CREATED:20241021T174323Z LAST-MODIFIED:20241021T174454Z UID:10000608-1729699200-1729706400@brain.uci.edu SUMMARY:Albert La Spada\, M.D.\, Ph.D. DESCRIPTION:The Charlie Dunlop School of Biological Sciences will host guest speaker Albert La Spada\, M.D.\, Ph.D.\, a professor of Pathology\, from the University of California\, Irvine\, for the Dean’s Distinguished Lecture. \nDefining the Mechanistic Basis of Neurodegenerative Proteinopathy: A 35 Year Genetic Odyssey \n  URL:https://brain.uci.edu/event/albert-la-spada-m-d-ph-d/ LOCATION:Crystal Cove Auditorium at the UCI Student Center\, 4113 Pereira Dr\, Irvine\, CA\, 92697-3800\, United States ATTACH;FMTTYPE=image/gif:https://brain.uci.edu/wp-content/uploads/sites/49/2024/10/Deans-Distinguished-Lecture.gif END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20241022T160000 DTEND;TZID=America/Los_Angeles:20241022T170000 DTSTAMP:20260419T003943 CREATED:20240923T211204Z LAST-MODIFIED:20240923T212550Z UID:10000582-1729612800-1729616400@brain.uci.edu SUMMARY:Marcus Holmes\, Ph.D. DESCRIPTION:UCI Center for the Neurobiology of Learning and Memory\, UCI Brain\, and UCI Conte Center will host guest speaker Dr. Marcus Holmes\, Professor of Government\, Chair of the Department of Government\, Director of the Political Psychology and International Relations Lab\, and Co-Director of the Social Science Research Methods Center from The College of William and Mary. \nThe Social Neuroscience Behind Face-to-Face Diplomacy? URL:https://brain.uci.edu/event/marcus-holmes-ph-d/ LOCATION:CNLM Herklotz Conference Center and Virtually via Zoom ATTACH;FMTTYPE=image/png:https://brain.uci.edu/wp-content/uploads/sites/49/2024/09/Untitled-design-8.png ORGANIZER;CN="UCI Center for the Neurobiology of Learning and Memory%2C UCI Brain%2C and UCI Conte Center":MAILTO:jweinsto@hs.uci.edu END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20241022T100000 DTEND;TZID=America/Los_Angeles:20241022T110000 DTSTAMP:20260419T003943 CREATED:20240205T211305Z LAST-MODIFIED:20240826T211759Z UID:10000483-1729591200-1729594800@brain.uci.edu SUMMARY:Daniele Canzio\, PhD DESCRIPTION:The Center for Neural Circuit Mapping will host guest speaker Dr. Daniele Canzio\, Assistant Professor of Neurology at the Weill Institute for Neurosciences\, University of California\, San Francisco. \nHow do neurons recognize self from non-self? \nMy lab investigates how neurons distinguish self from non-self\, a process also known as neural self-avoidance. This process is critical for the establishment of neural wiring patterns during development. We are particularly interested in the role of genome architecture and epigenetic gene silencing in the generation of the transcriptional diversity underlying the process of neural self-avoidance in the mammalian brain. URL:https://brain.uci.edu/event/daniele-canzio-phd/ LOCATION:Interdisciplinary Science and Engineering Building (ISEB) and Virtually Via Zoom\, 419 Physical Sciences Quad\, Irvine\, 92697\, United States ATTACH;FMTTYPE=image/png:https://brain.uci.edu/wp-content/uploads/sites/49/2024/02/Untitled-design-31.png END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20241018T083000 DTEND;TZID=America/Los_Angeles:20241018T100000 DTSTAMP:20260419T003943 CREATED:20241016T170752Z LAST-MODIFIED:20241016T170930Z UID:10000606-1729240200-1729245600@brain.uci.edu SUMMARY:Jack Gallant\, Ph.D. DESCRIPTION:UCI Center for Translational Vision Research will host guest speaker Dr. Jack Gallant\, a professor in the Department of Neuroscience and Co-director of the Brain Imaging Center (BIC)\, from the University of California\, Berkeley \nA biologically plausible hierarchical convolutional energy model explains V4 responses during natural vision \n  URL:https://brain.uci.edu/event/jack-gallant-ph-d/ LOCATION:Sue Gross Auditorium\, 854 Health Sciences Rd\, Irvine\, 92617\, United States CATEGORIES:Scientific,Staff,Students ATTACH;FMTTYPE=image/png:https://brain.uci.edu/wp-content/uploads/sites/49/2024/10/Untitled-design-28.png END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20241016T193000 DTEND;TZID=America/Los_Angeles:20241016T203000 DTSTAMP:20260419T003943 CREATED:20240724T191849Z LAST-MODIFIED:20240927T164530Z UID:10000556-1729107000-1729110600@brain.uci.edu SUMMARY:Lisa Feldman Barrett\, Ph.D. DESCRIPTION:The McGaugh-Gerard Lecture on Learning and Memory will host guest speaker Dr. Lisa Feldman Barrett\, University Distinguished Professor of Psychology at Northeastern University. \nThree Lessons About the Brain \n  \nEver wonder how your brain really works? Join us for the 3rd Annual McGaugh-Gerard Lecture on Learning and Memory by Dr. Lisa Feldman Barrett\, an author and expert in psychology and neuroscience\, as she breaks down three key ideas about the brain’s inner workings. In this talk\, you’ll learn: \n\nHow your brain’s most important job is keeping your body running smoothly.\nHow your brain is constantly predicting what will happen next rather than reacting to the world.\nHow feeling and thinking and even seeing follow from your brain’s plan for action; your brain prepares your behavior first and creates your lived experience in the process.\n\nDr. Barrett will show how these brain functions affect how you feel\, how you think\, and what you do. URL:https://brain.uci.edu/event/lisa-feldman-barrett-ph-d/ LOCATION:Irvine Barclay Theater\, 4242 Campus Drive\, Irvine\, CA\, 92612\, United States CATEGORIES:All,Community,Faculty,Scientific,Staff,Students,Students, Faculty, Staff Only ATTACH;FMTTYPE=image/jpeg:https://brain.uci.edu/wp-content/uploads/sites/49/2024/07/feldman-300.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20241015T100000 DTEND;TZID=America/Los_Angeles:20241015T110000 DTSTAMP:20260419T003943 CREATED:20240205T210855Z LAST-MODIFIED:20240826T211725Z UID:10000482-1728986400-1728990000@brain.uci.edu SUMMARY:Vahid Yaghmai\, MD\, MS\, FSAR DESCRIPTION:The Center for Neural Circuit Mapping will host guest speaker Dr. Vahid Yaghmai\, Professor and Chair in the Department of Radiological Sciences\, University of California\, Irvine \n“Medical Imaging Research: From Bench to Bedside”\n\n\n\nCurrent areas of basic and clinical research in Radiological Sciences department will be highlighted. An overview of resources in the preclinical and clinical settings will be provided. Clinical examples that highlight the state-of-the-art medical imaging technology available in Radiological Sciences will also be discussed. URL:https://brain.uci.edu/event/christina-kim-phd/ LOCATION:Interdisciplinary Science and Engineering Building (ISEB) and Virtually Via Zoom\, 419 Physical Sciences Quad\, Irvine\, 92697\, United States ATTACH;FMTTYPE=image/png:https://brain.uci.edu/wp-content/uploads/sites/49/2024/02/Untitled-design-6.png END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20241011T130000 DTEND;TZID=America/Los_Angeles:20241011T170000 DTSTAMP:20260419T003943 CREATED:20240925T222627Z LAST-MODIFIED:20240925T223103Z UID:10000592-1728651600-1728666000@brain.uci.edu SUMMARY:Masakazu Agetsuma\, Ph.D. DESCRIPTION:The Center for Neural Circuit Mapping will host guest speaker Dr. Masakazu Agetsuma\, Associate Professor of Neuroscience at the National Institute for Physiological Sciences\, Japan \n “Activity-dependent organization of prefrontal hub-networks for associative learning and signal transformation” \nAssociative learning is crucial for adapting to environmental changes. Interactions among neuronal populations involving the dorso-medial prefrontal cortex (dmPFC) in rodents are proposed to regulate associative memory. Although neural network remodeling is generally believed to underlie learning and memory\, how this process occurs to store and process associative memory remains one of the most critical open questions in the field. To tackle this question\, we developed a pipeline for longitudinal two-photon imaging and mathematical dissection of neural population activities in mouse dmPFC during fear-conditioning procedures\, enabling us to detect learning-dependent changes in the dmPFC information coding and network topology. After confirming that the dmPFC contributes to the expression of the conditioned responses (CR) by chemogenetic silencing\, we recorded neural population activities and analyzed them by regularized regression methods and graphical modeling. We found that fear conditioning drove dmPFC reorganization to generate a neuronal ensemble encoding CR\, which was characterized by enhanced internal coactivity and functional connectivity. Importantly\, neurons strongly responding to unconditioned stimuli during fear conditioning subsequently became hubs of this novel network and revealed enhanced association with conditioned stimuli (CS) specifically in the CR ensemble\, which may work as an information-processing neural network implementing CS-triggered CR. Altogether\, we demonstrate learning-dependent dynamic modulation of population coding structured on the activity-dependent formation of the hub network within the dmPFC. features reflecting the biomechanical constraints and evolutionary origins of these motor control systems.” URL:https://brain.uci.edu/event/masakazu-agetsuma-phd/ LOCATION:Plumwood House Room 166\, 1003 Health Sciences Rd\, Irvine\, CA 92617\, Irvine\, CA\, 92697-3800\, United States CATEGORIES:Faculty,Scientific,Staff,Students,Students, Faculty, Staff Only ATTACH;FMTTYPE=image/png:https://brain.uci.edu/wp-content/uploads/sites/49/2024/09/Jeffrey-Krichmar-Ph.D.-9.png END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20241004T080000 DTEND;TZID=America/Los_Angeles:20241004T180000 DTSTAMP:20260419T003943 CREATED:20240827T171255Z LAST-MODIFIED:20241001T173341Z UID:10000574-1728028800-1728064800@brain.uci.edu SUMMARY:2024 Second Annual Symposium for the Center for Neurotherapeutics DESCRIPTION:The purpose of the Symposium will be to familiarize attendees with the UCI Center for\nNeurotherapeutics and introduce attendees to the exciting translational\nneuroscience research happening right on our campus and in labs across the country. We\nhope that attendees will: \n\nLearn about the vision that drives us at the UCI Center for Neurotherapeutics and our\nongoing effort to advance drug development on campus.\nBecome acquainted with cutting-edge approaches being applied to develop innovative\nmodels and novel therapeutic solutions for neurological diseases. Lecture topics will\ninclude drug discovery and high-throughput screening methods to identify rational\ndrug targets. Experts from diverse disciplines will explain how they are tackling the\nchallenge of delivering small molecules and biological agents across the blood-brain\nbarrier.\nAppreciate the many opportunities for cross-disciplinary interaction and collaboration\nin this field. Our number one core value at the UCI Center for Neurotherapeutics is to\npromote collaboration across campus\, especially between faculty in the physical\nsciences and the biological sciences. We believe that only by combining such multi-\ndisciplinary expertise and diverse perspectives will it be possible to unlock new\navenues of discovery and accelerate progress toward developing meaningful solutions\nfor therapy development.\n\nOur exceptional line-up of guest speakers and UCI faculty speakers include: \n\nAnabella Villalobos (Biogen); Neurological/Rare Disease Therapies\nDonna Huryn (University of Pennsylvania); Academic Drug Discovery Challenges\nEthan Lippmann (Vanderbilt); siRNA Brain Delivery via Albumin\nSu Guo (UC San Francisco); GPCR Targeting in Parkinson’s\nHang Lu (Georgia Tech); Microtechnology & AI in Drug Screening\n Errol Arkilic (UC Irvine); Beall Applied Innovation\nLeslie Thompson (UC Irvine); Huntington’s Disease Treatment Advances\nJennifer Prescher (UC Irvine); Nature-Inspired Imaging Tools\nChristopher Hughes (UC Irvine); Blood-Brain Barrier Neurovascular Model\nMelanie Cocco (UC Irvine); Voxelotor for Red Blood Cell Modulation\n\nWhether you are a student\, postdoctoral trainee\, faculty member\, or staff member\, we\nencourage you to join us\, so please mark your calendars! \nRegistration is free! \nPlease register by Friday\, September 27\, 2024. URL:https://brain.uci.edu/event/2024-second-annual-symposium-for-the-center-for-neurotherapeutics/ LOCATION:Samueli Integrative Health Institute Sue Gross Auditorium\, 856 Health Sciences Quad\, Irvine\, 92697\, United States CATEGORIES:All,Community,Faculty,Scientific,Staff,Students,Students, Faculty, Staff Only ATTACH;FMTTYPE=image/png:https://brain.uci.edu/wp-content/uploads/sites/49/2024/08/Picture1.png END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20240924T100000 DTEND;TZID=America/Los_Angeles:20240924T110000 DTSTAMP:20260419T003943 CREATED:20240205T210428Z LAST-MODIFIED:20240826T211031Z UID:10000481-1727172000-1727175600@brain.uci.edu SUMMARY:Wei-Chung Lee\, PhD DESCRIPTION:The Center for Neural Circuit Mapping will host guest speaker Dr. Wei-Chung Lee\, Assistant Professor of Neurology at Harvard University. \n“Circuit Motifs of Sensorimotor Integration”\n\n\nNeuronal circuits transform sensory information into behavior. I will present our recent work to understand the neuronal circuit basis of decision making and motor control. First\, we studied synaptic connectivity underlying choice-selective activity in the mouse posterior parietal cortex (PPC) during a perceptual decision-making task. Using a combination of virtual-reality behavior\, two-photon calcium imaging\, connectomics\, and circuit modeling\, we analyzed how synaptic connections between PPC neurons relate to their function. Our results provide evidence for how synaptic connectivity in cortical circuits supports a learned decision-making task. Second\, we examined the wiring logic of premotor circuits controlling the Drosophila leg and wing. Using connectomics\, we found that premotor networks organize into modules linking motor neurons innervating muscles with related functions. By comparing the architectures of leg and wing motor control systems within the same animal\, we identified common principles of premotor network organization and specialized features reflecting the biomechanical constraints and evolutionary origins of these motor control systems. URL:https://brain.uci.edu/event/wei-chung-lee-phd/ LOCATION:Interdisciplinary Science and Engineering Building (ISEB) and Virtually Via Zoom\, 419 Physical Sciences Quad\, Irvine\, 92697\, United States ATTACH;FMTTYPE=image/png:https://brain.uci.edu/wp-content/uploads/sites/49/2024/02/Untitled-design-5.png END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20240919T103000 DTEND;TZID=America/Los_Angeles:20240919T113000 DTSTAMP:20260419T003943 CREATED:20240909T171729Z LAST-MODIFIED:20240909T171729Z UID:10000579-1726741800-1726745400@brain.uci.edu SUMMARY:Benjamin Gunn\, PhD DESCRIPTION:The Department of Anatomy & Neurobiology seminar will host guest speaker Dr. Benjamin Gunn\, Project Scientist at University of California\, Irvine \nAn analysis of the primary hippocampal circuit implications and applications \nDespite intense interest in hippocampal contributions to behavior\, surprisingly little is known about how cortical signals are processed across even the basic multi-stage circuit. Here\, I will describe the first input/output relationship for the primary hippocampal circuit. Results identify a novel role for recurrent CA3 activity in driving throughput that challenges the notion of the tri-synaptic circuit\, while the presence of low pass filters dictates the nature of effective input frequencies and patterns. Although the simplest circuit operation\, signal throughput is critical for the execution of more complex processes required for hippocampus-dependent memory processing — how these findings place constraints upon circuit performance and the potential for different operational states will be discussed. These findings open the way to novel analyses of how the hippocampus and its contributions to behavior may be influenced in physiological and pathophysiological states. In this regard\, I will provide evidence for alterations in hippocampal circuit function following single-housing that are associated with deficits in cognitive function and other behaviors associated with depression. URL:https://brain.uci.edu/event/benjamin-gunn-phd/ LOCATION:Plumwood House\, 1003 Health Sciences Rd\, Irvine\, CA 92617\, Irvine\, CA\, 92697\, United States ATTACH;FMTTYPE=image/png:https://brain.uci.edu/wp-content/uploads/sites/49/2024/09/Untitled-design-4.png END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20240910T100000 DTEND;TZID=America/Los_Angeles:20240910T110000 DTSTAMP:20260419T003943 CREATED:20240826T210444Z LAST-MODIFIED:20240826T211716Z UID:10000566-1725962400-1725966000@brain.uci.edu SUMMARY:Jing Zhang\, PhD DESCRIPTION:The Center for Neural Circuit Mapping will host guest speaker Dr. Jing Zhang\, Assistant Professor in the Department of Computer Science\, University of California\, Irvine. URL:https://brain.uci.edu/event/jing-zhang-phd/ LOCATION:Interdisciplinary Science and Engineering Building (ISEB) and Virtually Via Zoom\, 419 Physical Sciences Quad\, Irvine\, 92697\, United States ATTACH;FMTTYPE=image/png:https://brain.uci.edu/wp-content/uploads/sites/49/2024/08/Untitled-design-4.png END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20240906T080000 DTEND;TZID=America/Los_Angeles:20240906T151500 DTSTAMP:20260419T003943 CREATED:20240829T160908Z LAST-MODIFIED:20240829T161027Z UID:10000576-1725609600-1725635700@brain.uci.edu SUMMARY:35th Annual Southern California Alzheimer’s Disease Research Conference DESCRIPTION:Register for the 35th Annual Southern California Alzheimer’s Disease Research Conference\, Advances in Dementia Care\, hosted by the UCI Institute for Memory Impairments and Neurological Disorders (UCI MIND) in partnership with Alzheimer’s Orange County and Alzheimer’s Association Orange County. This year the conference will examine the important advances being made in the diagnosis\, treatment\, and care for people living with dementia. Topics will include genetic testing\, blood tests\, disease modifying therapies\, treatments for behavioral symptoms\, equity and access\, the rise of pseudomedicine\, and care navigator programs. URL:https://brain.uci.edu/event/35th-annual-southern-california-alzheimers-disease-research-conference/ LOCATION:Hilton Irvine and Virtual\, 18800 MacArthur Blvd\, Irvine\, CA\, 92612\, United States CATEGORIES:All ATTACH;FMTTYPE=image/png:https://brain.uci.edu/wp-content/uploads/sites/49/2024/08/e16b1d-ea87-41d4-83e5-5566b4f3f7b8.png END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20240813T153000 DTEND;TZID=America/Los_Angeles:20240813T170000 DTSTAMP:20260419T003943 CREATED:20240813T192054Z LAST-MODIFIED:20240813T192129Z UID:10000559-1723563000-1723568400@brain.uci.edu SUMMARY:Niels Niethard PhD DESCRIPTION:The Department of Cognitive Sciences will host guest speaker\, Dr. Niels Niethard\, from University of Tubingen \nSleep oscillations and synaptic plasticity: A circuit perspective URL:https://brain.uci.edu/event/niels-niethard-phd/ LOCATION:SSPA 2112\, Social Science Plaza A (SSPA) Room 2112\, Irvine\, CA\, 92697-3800\, United States ATTACH;FMTTYPE=image/png:https://brain.uci.edu/wp-content/uploads/sites/49/2024/08/Untitled-design-1.png END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20240709T160000 DTEND;TZID=America/Los_Angeles:20240709T170000 DTSTAMP:20260419T003943 CREATED:20240627T220052Z LAST-MODIFIED:20240627T220420Z UID:10000546-1720540800-1720544400@brain.uci.edu SUMMARY:UCI Conte Center Seminar Series with Debra Bangasser\, PhD DESCRIPTION:The UCI Conte Center Seminar Series will host guest speaker Dr. Debra Bangasser\, Associate Director at the Center for Behavioral Neuroscience at Georgia State University. Pastries and coffee will be provided. \nEarly resource scarcity causes lasting changes in cognition and motivated behavior URL:https://brain.uci.edu/event/uci-conte-center-seminar-series-with-debra-bangasser-phd/ LOCATION:Plumwood/Showa Denko Lecture Hall ATTACH;FMTTYPE=image/png:https://brain.uci.edu/wp-content/uploads/sites/49/2024/06/Untitled-design-12.png END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20240709T100000 DTEND;TZID=America/Los_Angeles:20240709T110000 DTSTAMP:20260419T003943 CREATED:20240531T164916Z LAST-MODIFIED:20240625T143634Z UID:10000540-1720519200-1720522800@brain.uci.edu SUMMARY:Dorote Lucci\, Ph.D. DESCRIPTION:The Center for Neural Circuit Mapping will host guest speaker Dr. Dorote Lucci\, Chair of the Global Conference on Advancing Mental Health. \nExploring the Intersection of AI\, Neuroscience\, and Transformative Learning: A Whole-Person Perspective from Transpersonal Psychology URL:https://brain.uci.edu/event/dorote-lucci-ph-d/ LOCATION:Interdisciplinary Science and Engineering Building (ISEB) and Virtually Via Zoom\, 419 Physical Sciences Quad\, Irvine\, 92697\, United States CATEGORIES:Faculty,Scientific,Staff,Students,Students, Faculty, Staff Only ATTACH;FMTTYPE=image/jpeg:https://brain.uci.edu/wp-content/uploads/sites/49/2024/05/lucci.jpg END:VEVENT END:VCALENDAR