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DTSTART;TZID=America/Los_Angeles:20231128T110000
DTEND;TZID=America/Los_Angeles:20231128T120000
DTSTAMP:20260420T085715
CREATED:20231009T211005Z
LAST-MODIFIED:20231009T214419Z
UID:10000429-1701169200-1701172800@brain.uci.edu
SUMMARY:Anna K. Gillespie\, Ph.D.
DESCRIPTION:CNLM Colloquium Series \nSteps toward exploring the therapeutic potential of hippocampal replay \nJoin the Center for the Neurobiology of Learning and Memory (CNLM) for a hybrid event featuring Dr. Anna Gillespie\, assistant professor of biological structure\, lab medicine\, and pathology at University of Washington. This event will be held in-person in the Herklotz Conference Center and virtually via Zoom. \n \nDescription: \nExecuting memory-guided behavior requires storage of information about experience and later recall of that information to inform choices. Hippocampal sharp-wave ripple (SWR) events are associated with the time-compressed “replay” of representations of past experience\, and multiple correlative and causal studies have demonstrated that SWRs critically contribute to these cognitive functions. Consistent with its role in memory processes\, changes in SWRs have been reported concurrent with memory impairment in several rodent models of Alzheimer’s disease. Rescuing replay in Alzheimer’s could thus improve memory symptoms; however\, our current options for promoting physiologically relevant replay are quite limited. To address this gap\, we developed a neurofeedback paradigm for rats in which the real-time detection of SWRs triggers the delivery of positive reinforcement (food reward). In young adult animals\, this training protocol increased the prevalence of task-relevant replay during the targeted neurofeedback period by changing the temporal dynamics of SWR occurrence\, and was also associated with neural and behavioral forms of compensation after the targeted period. This work demonstrates that subjects can learn to use neurofeedback to modulate physiologically relevant patterns of hippocampal network activity and lays the foundation for future work in subjects with compromised replay\, such as rodent models of Alzheimer’s disease.
URL:https://brain.uci.edu/event/anna-k-gillespie-ph-d/
LOCATION:CNLM Herklotz Conference Center and Virtually via Zoom
CATEGORIES:Faculty,Scientific,Staff,Students,Students, Faculty, Staff Only
ATTACH;FMTTYPE=image/jpeg:https://brain.uci.edu/wp-content/uploads/sites/49/2023/10/anna-gillespie-250.jpg
ORGANIZER;CN="UCI Center for the Neurobiology of Learning and Memory":MAILTO:memory@uci.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20240116T100000
DTEND;TZID=America/Los_Angeles:20240116T110000
DTSTAMP:20260420T085715
CREATED:20240125T183718Z
LAST-MODIFIED:20240125T183828Z
UID:10000461-1705399200-1705402800@brain.uci.edu
SUMMARY:Donghui Zhu\, PhD
DESCRIPTION:SUNY Empire Innovation Professor Donghui Zhu\, PhD from Stony Brook University Presents: \n“Amyloid beta glycation leads to neuronal mitochondrial dysfunction and Alzheimer’s pathogenesis via VDAC1-dependent mtDNA efflux” \nHybrid: ISEB 1200 & Zoom
URL:https://brain.uci.edu/event/donghui-zhu-phd/
LOCATION:Interdisciplinary Science and Engineering Building (ISEB) and Virtually Via Zoom\, 419 Physical Sciences Quad\, Irvine\, 92697\, United States
ATTACH;FMTTYPE=image/jpeg:https://brain.uci.edu/wp-content/uploads/sites/49/2024/01/donghui_zhu2.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20240116T160000
DTEND;TZID=America/Los_Angeles:20240116T170000
DTSTAMP:20260420T085715
CREATED:20231207T161611Z
LAST-MODIFIED:20231207T162001Z
UID:10000453-1705420800-1705424400@brain.uci.edu
SUMMARY:UCI Conte Center Seminar Series with Pat Levitt\, PhD
DESCRIPTION:“Functional Implications of Developmental Heterogeneity” by Pat Levitt\, PhD\, Chief Scientific Officer\, Senior Vice President and Director\, The Saban Research Institute\, Simms/Mann Chair in Developmental Neurogenetics\, Children’s Hospital Los Angeles\, WM Keck Provost Professor of Neurogenetics\, Keck School of Medicine of USC
URL:https://brain.uci.edu/event/uci-conte-center-seminar-series-with-pat-levitt-phd/
LOCATION:Plumwood/Showa Denko Lecture Hall
CATEGORIES:All
ATTACH;FMTTYPE=image/png:https://brain.uci.edu/wp-content/uploads/sites/49/2023/12/UCI-Conte-Center-Seminar-Series-with-Pat-Levitt-PhD.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20240125T080000
DTEND;TZID=America/Los_Angeles:20240125T170000
DTSTAMP:20260420T085715
CREATED:20240125T235339Z
LAST-MODIFIED:20240125T235339Z
UID:10000470-1706169600-1706202000@brain.uci.edu
SUMMARY:Weizhe Hong\, PhD
DESCRIPTION:Professor of Biological Chemistry & Neurobiology Weizhe Hong\, PhD from the University of California\, Los Angeles Presents: \n“TBD” \nHybrid: ISEB 1200 & Zoom \n 
URL:https://brain.uci.edu/event/weizhe-hong-phd/
LOCATION:Interdisciplinary Science and Engineering Building (ISEB) and Virtually Via Zoom\, 419 Physical Sciences Quad\, Irvine\, 92697\, United States
ATTACH;FMTTYPE=image/png:https://brain.uci.edu/wp-content/uploads/sites/49/2024/01/Untitled-design-16.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20240206T110000
DTEND;TZID=America/Los_Angeles:20240206T120000
DTSTAMP:20260420T085715
CREATED:20231009T213853Z
LAST-MODIFIED:20231205T181600Z
UID:10000431-1707217200-1707220800@brain.uci.edu
SUMMARY:Elizabeth A. Buffalo\, Ph.D.
DESCRIPTION:CNLM Colloquium Series \nJoin the Center for the Neurobiology of Learning and Memory (CNLM) for a hybrid event featuring Dr. Elizabeth A. Buffalo\, professor and chair of physiology and biophysics at the University of Washington. \nThis event will be held in-person in the Herklotz Conference Center and virtually via Zoom. \nNeural Dynamics of Memory Formation in the Primate Hippocampus  \n \nDescription:  \nOur understanding of the hippocampus has been framed by two landmark discoveries: the discovery by Scoville and Millner that hippocampal damage causes profound and persistent amnesia and the discovery by O’Keefe and Dostrovsky of hippocampal place cells in rodents. However\, it has been unclear to what extent spatial representations are present in the primate brain and how to reconcile these representations with the known mnemonic function of this region. I will discuss a series of experiments that have examined neural activity in the hippocampus in monkeys performing behavioral tasks including foraging and spatial memory tasks in a virtual environment. These data demonstrate that behavioral task structure has a significant influence on hippocampal activity\, with neurons responding to all salient events within the task. Taken together\, these data are consistent with the idea that activity in the hippocampus tracks ongoing experience in support of memory formation.
URL:https://brain.uci.edu/event/elizabeth-buffalo-ph-d/
LOCATION:CNLM Herklotz Conference Center and Virtually via Zoom
CATEGORIES:Faculty,Scientific,Staff,Students,Students, Faculty, Staff Only
ATTACH;FMTTYPE=image/jpeg:https://brain.uci.edu/wp-content/uploads/sites/49/2023/10/beth-buffalo-250.jpg
ORGANIZER;CN="UCI Center for the Neurobiology of Learning and Memory":MAILTO:memory@uci.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20240213T110000
DTEND;TZID=America/Los_Angeles:20240213T120000
DTSTAMP:20260420T085715
CREATED:20240124T220420Z
LAST-MODIFIED:20240125T233901Z
UID:10000459-1707822000-1707825600@brain.uci.edu
SUMMARY:Katalin Gothard\, Ph.D.
DESCRIPTION:Join Dr. Katalin Gothard in the James L. McGaugh Distinguished Seminar Series In-Person or over Zoom! \n“A context-dependent switch from sensing to feeling in the primate amygdala”\n\nKatalin M. Gothard\, M.D.\, Ph.D.\nProfessor of Physiology\, Neurology\, and Neuroscience The University of Arizona College of Medicine Department of Physiology \nAbstract: \nTactile signals elicited in the periphery by social and affective touch acquire emotional significance in the brain. As the amygdala processes the valence of all sensory stimuli\, we predicted that the positive valence of grooming would strongly activate the monkey amygdala. To test this hypothesis\, we compared neural activity in the amygdala and the primary somatosensory cortex in response to social grooming and gentle airflow delivered to the same areas of the skin. Neurons in the somatosensory cortex responded to both types of tactile stimuli. In the amygdala\, however\, neurons did not respond to individual grooming sweeps even though grooming elicited autonomic states indicative of positive affect. Instead of responses to individual touch stimuli\, a large proportion of neurons showed enhanced or suppressed baseline firing rates that persisted throughout a grooming bout. These changes were attributed to social context because the presence of the groomer alone could account for increases or decreases in baseline firing rates. It appears\, therefore\, that during grooming\, the amygdala stops responding to external inputs on a short time scale but remains responsive to social context\, and the associated affective states\, on longer time scales.
URL:https://brain.uci.edu/event/james-l-mcgaugh-distinguished-seminar-series/
LOCATION:CNLM Herklotz Conference Center and Virtually via Zoom
ATTACH;FMTTYPE=image/png:https://brain.uci.edu/wp-content/uploads/sites/49/2024/01/Untitled-design-6.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20240215T100000
DTEND;TZID=America/Los_Angeles:20240215T110000
DTSTAMP:20260420T085715
CREATED:20240125T184404Z
LAST-MODIFIED:20240125T234347Z
UID:10000462-1707991200-1707994800@brain.uci.edu
SUMMARY:Sandeep Robert Datta\, MD\, PhD
DESCRIPTION:Professor of Neurobiology Sandeep Robert Datta\, MD\, PhD from Harvard Medical School presents: \n“Using Machine Learning to Discover How the Brain Builds Behavior” \nHybrid: ISEB 1200 & Zoom
URL:https://brain.uci.edu/event/sandeep-robert-datta-md-phd/
LOCATION:Interdisciplinary Science and Engineering Building (ISEB) and Virtually Via Zoom\, 419 Physical Sciences Quad\, Irvine\, 92697\, United States
ATTACH;FMTTYPE=image/png:https://brain.uci.edu/wp-content/uploads/sites/49/2024/01/Untitled-design-13.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20240215T110000
DTEND;TZID=America/Los_Angeles:20240215T120000
DTSTAMP:20260420T085715
CREATED:20240202T182333Z
LAST-MODIFIED:20240202T182333Z
UID:10000477-1707994800-1707998400@brain.uci.edu
SUMMARY:Garret Anderson\, PhD
DESCRIPTION:The department of Anatomy & Neurobiology will host guest speaker Garret Anderson from UC Riverside\, who will give a talk on ““Latrophilin cell-type specific expression and implications for neural circuit development”
URL:https://brain.uci.edu/event/garret-anderson-phd/
LOCATION:Plumwood House\, 1003 Health Sciences Rd\, Irvine\, CA 92617\, Irvine\, CA\, 92697\, United States
CATEGORIES:Community,Faculty,Scientific,Staff,Students
ATTACH;FMTTYPE=image/png:https://brain.uci.edu/wp-content/uploads/sites/49/2024/02/Capture.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20240220T100000
DTEND;TZID=America/Los_Angeles:20240220T110000
DTSTAMP:20260420T085715
CREATED:20240125T191348Z
LAST-MODIFIED:20240125T235133Z
UID:10000463-1708423200-1708426800@brain.uci.edu
SUMMARY:Michelle Jones-London\, PhD
DESCRIPTION:Chief of Office of Programs to Enhance Neuroscience Workforce Diversity Michelle Jones-London\, PhD from NIH/NINDS presents: \n“An OPEN Conversation: NINDS Strategies for Enhancing the Diversity of Neuroscience Researchers” \nHybrid: ISEB 1200 & Zoom \n 
URL:https://brain.uci.edu/event/michelle-jones-london-phd/
LOCATION:Interdisciplinary Science and Engineering Building (ISEB) and Virtually Via Zoom\, 419 Physical Sciences Quad\, Irvine\, 92697\, United States
ATTACH;FMTTYPE=image/png:https://brain.uci.edu/wp-content/uploads/sites/49/2024/01/Untitled-design-12.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20240223T110000
DTEND;TZID=America/Los_Angeles:20240223T120000
DTSTAMP:20260420T085715
CREATED:20240129T160947Z
LAST-MODIFIED:20240129T161317Z
UID:10000471-1708686000-1708689600@brain.uci.edu
SUMMARY:Frances Wiseman\, PhD
DESCRIPTION:The CFAR-DS Research Seminar Series hosts scientists from UC Irvine and beyond who conduct research focused on Down syndrome\, including research ranging from human participants to animal models. This seminar series is intended for scientists\, although all are welcome to attend. \nOn Friday\, February 23\, 2024 at 11:00 am Pacific Time please join us via Zoom for a presentation by Frances Wiseman\, PhD titled “Understanding differences in Down syndrome – Alzheimer’s disease: a focus on amyloid-β formation and response.” \nFrances Wiseman\, PhD is Programme Leader for Animal Models at the UK Dementia Research Institute. Dr Wiseman will discuss her group’s recent research using combinations of Down syndrome and amyloid-β accumulation mouse models; to understand how additional copies of chromosome 21 genes other than APP may modulate Alzheimer’s disease development in people who have Down syndrome. This will include a discussion of Mumford et al 2022\, PMID: 35835549 and recent follow-up unpublished data examining the interferon amyloid-β response in a new mouse model of Down syndrome-Alzheimer’s disease.
URL:https://brain.uci.edu/event/uci-center-for-aging-research-in-down-syndrome-seminar/
LOCATION:Zoom\, Irvine\, CA\, 92697\, United States
CATEGORIES:Scientific
ATTACH;FMTTYPE=image/png:https://brain.uci.edu/wp-content/uploads/sites/49/2024/01/CFAR_DS-_Seminar_Wiseman_Feb2024_.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20240227T100000
DTEND;TZID=America/Los_Angeles:20240227T110000
DTSTAMP:20260420T085715
CREATED:20240125T201508Z
LAST-MODIFIED:20240125T234503Z
UID:10000464-1709028000-1709031600@brain.uci.edu
SUMMARY:Yimin Zou\, PhD
DESCRIPTION:Professor in the Department of Neurobiology of UCSD Yimin Zou\, PhD presents: \n“Planar cell polarity proteins in glutamatergic synapse formation and maintenance” \nHybrid: ISEB 1200 & Zoom
URL:https://brain.uci.edu/event/yimin-zou-phd/
LOCATION:Interdisciplinary Science and Engineering Building (ISEB) and Virtually Via Zoom\, 419 Physical Sciences Quad\, Irvine\, 92697\, United States
ATTACH;FMTTYPE=image/png:https://brain.uci.edu/wp-content/uploads/sites/49/2024/01/Untitled-design-14.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20240227T160000
DTEND;TZID=America/Los_Angeles:20240227T170000
DTSTAMP:20260420T085715
CREATED:20240125T215546Z
LAST-MODIFIED:20240125T233826Z
UID:10000466-1709049600-1709053200@brain.uci.edu
SUMMARY:Seth Pollak\, PhD
DESCRIPTION:Join Seth Pollak\, PhD for his talk at the UCI Conte Center Seminar Series \n“Re-thinking Adversity: Early Life Stress from the Child’s Perspective” by Seth Pollak\, PhD\, Vaughan-Bascom Distinguished Professor\, Department of Psychology\, Pediatrics\, Anthropology; LaFollette School of Public Affairs\, University of Wisconsin – Madison
URL:https://brain.uci.edu/event/uci-conte-center-seminar-series-with-seth-pollak-phd/
LOCATION:Plumwood/Showa Denko Lecture Hall
ATTACH;FMTTYPE=image/png:https://brain.uci.edu/wp-content/uploads/sites/49/2024/01/Untitled-design-9.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20240305T110000
DTEND;TZID=America/Los_Angeles:20240305T120000
DTSTAMP:20260420T085715
CREATED:20231009T215006Z
LAST-MODIFIED:20240229T212335Z
UID:10000432-1709636400-1709640000@brain.uci.edu
SUMMARY:J. David Jentsch\, Ph.D.
DESCRIPTION:CNLM Colloquium Series \nJoin the Center for the Neurobiology of Learning and Memory (CNLM) for a hybrid event featuring Dr. J. David Jentsch\, Distinguished Professor and Chair of psychology at Binghamton University. This event will be held in-person in the Herklotz Conference Center and virtually via Zoom. \nDiversity to the rescue: Identifying novel molecular regulators of addiction liability
URL:https://brain.uci.edu/event/j-david-jentsch-ph-d/
LOCATION:CNLM Herklotz Conference Center and Virtually via Zoom
CATEGORIES:Faculty,Scientific,Staff,Students,Students, Faculty, Staff Only
ATTACH;FMTTYPE=image/jpeg:https://brain.uci.edu/wp-content/uploads/sites/49/2023/10/jjentsch-2.jpg
ORGANIZER;CN="UCI Center for the Neurobiology of Learning and Memory":MAILTO:memory@uci.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20240312T100000
DTEND;TZID=America/Los_Angeles:20240312T110000
DTSTAMP:20260420T085715
CREATED:20240125T233026Z
LAST-MODIFIED:20240125T234220Z
UID:10000467-1710237600-1710241200@brain.uci.edu
SUMMARY:Keri Martinowich\, PhD
DESCRIPTION:Associate Professor\, Department of Psychiatry and Behavioral Sciences Keri Martinowich\, PhD from Johns Hopkins University Presents: \n“Cell type and spatially-resolved multiomic approaches for understanding human brain disorders” \nHybrid: ISEB 1200 & Zoom
URL:https://brain.uci.edu/event/keri-martinowich-phd/
LOCATION:Interdisciplinary Science and Engineering Building (ISEB) and Virtually Via Zoom\, 419 Physical Sciences Quad\, Irvine\, 92697\, United States
ATTACH;FMTTYPE=image/png:https://brain.uci.edu/wp-content/uploads/sites/49/2024/01/Untitled-design-11.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20240312T110000
DTEND;TZID=America/Los_Angeles:20240312T120000
DTSTAMP:20260420T085715
CREATED:20231009T215405Z
LAST-MODIFIED:20240130T163208Z
UID:10000433-1710241200-1710244800@brain.uci.edu
SUMMARY:Christian Bravo Rivera\, Ph.D.
DESCRIPTION:CNLM Colloquium Series \nJoin the Center for the Neurobiology of Learning and Memory (CNLM) for a hybrid event featuring Dr. Christian Bravo Rivera\, assistant professor of psychiatry\, anatomy\, and neurobiology. This event will be held in-person in the Herklotz Conference Center and virtually via Zoom. \nNeural circuits mediating reward approach and punishment avoidance conflict  \nReward is often present in risky environments\, requiring individuals to weigh the benefits of rewards against the associated risks. There are individuals that are unable to choose an appropriate response during risky reward opportunities and thus exhibit extreme avoidance or risky behaviors that can severely impair quality of life or endanger people. It is therefore necessary to characterize how neurons mediate reward approach and threat avoidance conflict. Here\, we adapted the platform-mediated avoidance conflict task (Bravo-Rivera et al 2014; Bravo-Rivera et al 2021)\, such that water-deprived mice could nose-poke for a light-signaled water reward and avoid a tone-signaled foot-shock by stepping onto a safety platform away from the reward port. Optogenetic activation of GABAergic neurons in the ventral pallidum invigorated reward approach at the expense of receiving shocks. Photometry recordings of glutamatergic neurons in the ventral pallidum and in the lateral habenula during conflict revealed that these structures promote avoidance and become inhibited during conflicted reward approach. These results suggest that a pallidal-habenula circuit mediates motivational conflict. We also compared behavioral conflict in male and female mice. Interestingly\, females stepped on the platform earlier than males after tone onset and took longer to leave the platform after tone offset. Males received more shocks than females and received more water reward than females by the end conflict training. Moreover\, females exhibited more tone-induced freezing and exhibited more frequent darting than males. These results suggest that females exhibit more avoidance behavior and less reward approach than males in the face of approach/avoidance conflict.
URL:https://brain.uci.edu/event/christian-bravo-rivera-ph-d/
LOCATION:CNLM Herklotz Conference Center and Virtually via Zoom
CATEGORIES:Faculty,Scientific,Staff,Students,Students, Faculty, Staff Only
ATTACH;FMTTYPE=image/jpeg:https://brain.uci.edu/wp-content/uploads/sites/49/2023/10/christian-bravo-rivera250.jpg
ORGANIZER;CN="UCI Center for the Neurobiology of Learning and Memory":MAILTO:memory@uci.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20240313T120000
DTEND;TZID=America/Los_Angeles:20240313T130000
DTSTAMP:20260420T085715
CREATED:20240307T161631Z
LAST-MODIFIED:20240307T163003Z
UID:10000511-1710331200-1710334800@brain.uci.edu
SUMMARY:Robert Zatorre\, PhD
DESCRIPTION:The Department of  Cognitive Sciences’ Colloquia Series presents guest speaker Dr. Robert Zatorre\, a professor in the Department of Psychology at Montreal Neurological Institute\, McGill University. \nFrom Perception to Pleasure. The Neuroscience of Music and Why We Love It \nMusic has existed in human societies since prehistory\, likely because it allows expression and regulation of emotion\, and evokes pleasure. In this lecture I will present findings from cognitive neuroscience that bear on the question of how we get from perception of sound patterns to pleasurable responses. I will first discuss evidence that corticocortical loops from and to the auditory cortex are responsible not only for perceptual processes but also for working memory\, sensory-motor\, and predictive functions that are essential to produce and perceive music. Then\, I will discuss neuroimaging and brain modulation studies from our lab focusing on the dopaminergic reward system\, its involvement in musical pleasure\, and what happens when that system is disrupted. I propose that pleasure in music arises from interactions between cortical loops that enable expectancies to emerge from perceived sound patterns\, and subcortical systems responsible for reward and valuation. This model integrates knowledge derived from basic neuroscience of reward mechanisms with independently derived concepts\, such as tension and anticipation\, from music theory. It may also serve as a way of thinking more broadly about aesthetic rewards.
URL:https://brain.uci.edu/event/robert-zatorre-phd/
LOCATION:Virtual via Zoom\, CA
ATTACH;FMTTYPE=image/png:https://brain.uci.edu/wp-content/uploads/sites/49/2024/03/Untitled-design-49.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20240314T110000
DTEND;TZID=America/Los_Angeles:20240314T120000
DTSTAMP:20260420T085715
CREATED:20240208T235302Z
LAST-MODIFIED:20240209T161652Z
UID:10000494-1710414000-1710417600@brain.uci.edu
SUMMARY:Krishna Jayant\, PhD
DESCRIPTION:The department of Anatomy & Neurobiology will host guest speaker Dr. Krishna Jayant\, an assistant professor from Purdue University. \nA translaminar space-time code supports touch-evoked traveling waves \nTraveling waves in mammalian cortex mediate vital aspects of animal cognition\, such as stimuli perception and working memory. Theoretical results suggest that these waves preserve timing and are critical for plasticity across long-range neural circuits. Therefore\, revealing the circuit mechanisms underlying sensory-evoked traveling waves is critical to understanding the neural basis of sensory perception. In this talk\, I will describe our recent efforts in using 2D nanotextured transparent ECoG style electrodes to map circuits orchestrating wave dynamics. Specifically\, by simultaneously mapping local-field-potentials and cellular ensemble dynamics (via 2P calcium imaging)\, we will describe the circuit features tied to traveling waves under active and passive whisker touch. We will show that in awake mice\, both passive and active whisker touch elicited traveling waves within and across barrels\, with both an early and late component lasting hundreds of milliseconds.  Strikingly\, wave dynamics reflected the value of the tactile stimulus\, and was found to be shaped by reinforcement learning. We will also describe how the late wave component is i) strongly modulated by motor feedback\, ii) complements a sparse ensemble pattern across layer 2/3 which we resolved via a balanced-state network model with distributed top-down feedback\, and iii) aligns with regenerative Layer 5 apical dendritic Ca2+ spikes. Our results establish a model in which translaminar spacetime patterns\, organized by motor cortical feedback\, sculpt touch-evoked traveling waves.
URL:https://brain.uci.edu/event/krishna-jayant-phd/
LOCATION:Plumwood House\, 1003 Health Sciences Rd\, Irvine\, CA 92617\, Irvine\, CA\, 92697\, United States
CATEGORIES:Community,Faculty,Scientific,Staff,Students
ATTACH;FMTTYPE=image/png:https://brain.uci.edu/wp-content/uploads/sites/49/2024/02/Untitled-design-48.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20240315T120000
DTEND;TZID=America/Los_Angeles:20240315T131500
DTSTAMP:20260420T085715
CREATED:20240131T220057Z
LAST-MODIFIED:20240131T220057Z
UID:10000472-1710504000-1710508500@brain.uci.edu
SUMMARY:Presidential Leadership and Disability
DESCRIPTION:The age of presidential candidates has become a salient concern\, but age is not the only physical factor that should concern citizens. Presidents can also suffer various forms of illness\, both physical and psychological. This talk highlights the nature of these concerns and how we might work to mitigate their impact on political outcomes. \nFree registration is open now: https://uci.zoom.us/webinar/register/WN_m5HtweYgSh6t9sGnAa_hOQ#/registration \nFor more details\, please visit: https://sites.uci.edu/centerforneuropolitics/
URL:https://brain.uci.edu/event/presidential-leadership-and-disability/
LOCATION:Zoom Webinar
CATEGORIES:All,Community,Faculty,Scientific,Staff,Students
ATTACH;FMTTYPE=image/jpeg:https://brain.uci.edu/wp-content/uploads/sites/49/2024/01/Neuropolitics-Social-Ad_FridayMarch5th2024_-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20240319T100000
DTEND;TZID=America/Los_Angeles:20240319T110000
DTSTAMP:20260420T085715
CREATED:20240125T233442Z
LAST-MODIFIED:20240125T234139Z
UID:10000468-1710842400-1710846000@brain.uci.edu
SUMMARY:Anubhuti Goel\, PhD
DESCRIPTION:Assistant Professor of the Department of Psychology Anubhuti Goel\, PhD from UC Riverside Presents: \n“TBD” \nHybrid: ISEB 1200 & Zoom
URL:https://brain.uci.edu/event/anubhuti-goel-phd/
LOCATION:Interdisciplinary Science and Engineering Building (ISEB) and Virtually Via Zoom\, 419 Physical Sciences Quad\, Irvine\, 92697\, United States
ATTACH;FMTTYPE=image/png:https://brain.uci.edu/wp-content/uploads/sites/49/2024/01/Untitled-design-10.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20240326T090000
DTEND;TZID=America/Los_Angeles:20240326T160000
DTSTAMP:20260420T085715
CREATED:20240201T190403Z
LAST-MODIFIED:20240201T202202Z
UID:10000473-1711443600-1711468800@brain.uci.edu
SUMMARY:Conte Center @UCI 11th Annual Symposium
DESCRIPTION:11th Annual Symposium \nTuesday\, March 26\, 2024\n9:00am – 4:00pm \nThe Power and Potential of Big Data and Consortia\nfor Studying Mental Health and Disease \nKEYNOTE SPEAKERS:\n \nChristina Chambers\, Ph.D.\, M.P.H.\nDistinguished Professor\, Department of Pediatrics\nCo-Director\, Center for Better Beginnings\nAssociate Director\, Altman Clinical &\nTranslational Research Institute\nUniversity of California\, San Diego \n \nChristine M. Heim\, PhD\nDirector of Institute of Medical Psychology at Charité – Universitätsmedizin Berlin \n \nCaroline Nievergelt\, PhD\nProfessor\,\nDepartment of Psychiatry\nUniversity of California\, San Diego \nRegister for the 11th Annual Symposium \nCall for Abstracts and Posters \n \nLocation:\nBeckman Center Of The National Academies Of Sciences\, Engineering\, and Medicine\n100 Academy\, Irvine\, CA 92617 \nRegistration is free. \nQuestions? Please reach out to James Weinstock – jweinsto@uci.edu
URL:https://brain.uci.edu/event/conte-center-uci-11th-annual-symposium/
LOCATION:Beckman Center of the National Academies of Sciences & Engineering\, 100 Academy Wy\, Irvine\, CA\, 92617\, United States
ATTACH;FMTTYPE=image/png:https://brain.uci.edu/wp-content/uploads/sites/49/2024/02/Untitled-design-17.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20240409T100000
DTEND;TZID=America/Los_Angeles:20240409T110000
DTSTAMP:20260420T085715
CREATED:20240125T235047Z
LAST-MODIFIED:20240327T223638Z
UID:10000469-1712656800-1712660400@brain.uci.edu
SUMMARY:Xiaoyin Chen\, Ph.D.
DESCRIPTION:Understanding cortical organization using in situ sequencing \nThe UCI Center for Neural Circuit Mapping will host Xiaoyin Chen\, PhD\, assistant investigator of the Barcoded Connectomics Program at the  Allen Institute.
URL:https://brain.uci.edu/event/xiaoyin-chen-phd/
LOCATION:Interdisciplinary Science and Engineering Building (ISEB) and Virtually Via Zoom\, 419 Physical Sciences Quad\, Irvine\, 92697\, United States
CATEGORIES:Faculty,Scientific,Staff,Students,Students, Faculty, Staff Only
ATTACH;FMTTYPE=image/png:https://brain.uci.edu/wp-content/uploads/sites/49/2024/01/Untitled-design-15.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20240409T110000
DTEND;TZID=America/Los_Angeles:20240409T120000
DTSTAMP:20260420T085715
CREATED:20231009T215849Z
LAST-MODIFIED:20240213T192635Z
UID:10000434-1712660400-1712664000@brain.uci.edu
SUMMARY:Nanthia Suthana\, Ph.D.
DESCRIPTION:Join the Center for the Neurobiology of Learning and Memory (CNLM) for a hybrid event featuring Dr. Nanthia Suthana\, associate professor-in-residence at the University of California\, Los Angeles. This event will be held in-person in the Herklotz Conference Center and virtually via Zoom. \nUnraveling Memories on the Go: Insights from Mobile Intracranial EEG Recordings in Humans \n \nDescription: \nRecent technology enables the study of deep brain activity during memory phenomena in ambulatory humans navigating through real or virtual environments. Through these methods\, we have shown dynamic modulation of hippocampal\, entorhinal\, and amygdala activity by factors like movement speed\, eye movements\, emotional valence and memory success. This presentation will provide an overview of these findings and explore potential clinical applications\, particularly in treating neuropsychiatric disorders such as post-traumatic stress disorder.
URL:https://brain.uci.edu/event/nanthia-suthana-ph-d/
LOCATION:CNLM Herklotz Conference Center and Virtually via Zoom
CATEGORIES:Faculty,Scientific,Staff,Students,Students, Faculty, Staff Only
ATTACH;FMTTYPE=image/jpeg:https://brain.uci.edu/wp-content/uploads/sites/49/2023/10/nanthia-suthana-profile.jpg
ORGANIZER;CN="UCI Center for the Neurobiology of Learning and Memory":MAILTO:memory@uci.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20240411T110000
DTEND;TZID=America/Los_Angeles:20240411T123000
DTSTAMP:20260420T085715
CREATED:20240206T192557Z
LAST-MODIFIED:20240327T222339Z
UID:10000492-1712833200-1712838600@brain.uci.edu
SUMMARY:Joshua Johansen\, PhD
DESCRIPTION:The department of Anatomy & Neurobiology will host guest speaker Dr. Joshua Johansen from the RIKEN Center for Brain Science \nConstructing Emotional Representations in the Brain \nDescription: \nInnately aversive experiences profoundly alter brain processing to produce emotional states which coordinate physiological and behavioral responses and instruct memory formation. However\, more complex emotions occur through an evaluation of the environment in the context of past experiences and the current physiological condition of the organism. My lab studies the neural circuits and cell coding mechanisms which translate aversive experiences into simple and complex emotional states in the brain to regulate memory formation and guide behavior. I will describe our recent work identifying a brainstem neural circuit which conveys both external-sensory and internal-motor features of innately aversive experiences to create a sensorimotor state in the amygdala for producing aversive memory formation. Contrasting with this bottom-up circuit\, we’ve also found that the medial prefrontal cortex encodes more complex emotional states by building an internal associative model to perform emotional inference through top-down projections to the amygdala. These studies support a new hierarchical circuit model of emotion in which sensory\, bodily and cognitive factors shape neural processing across distributed neural circuits to adaptively and flexibly control defensive responding and memory formation.
URL:https://brain.uci.edu/event/anatomy-neurobiology-seminar-dr-joshua-johansen/
LOCATION:Plumwood House\, 1003 Health Sciences Rd\, Irvine\, CA 92617\, Irvine\, CA\, 92697\, United States
CATEGORIES:Community,Faculty,Scientific,Staff,Students
ATTACH;FMTTYPE=image/jpeg:https://brain.uci.edu/wp-content/uploads/sites/49/2024/02/j.johansen.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20240416T100000
DTEND;TZID=America/Los_Angeles:20240416T110000
DTSTAMP:20260420T085715
CREATED:20240201T200708Z
LAST-MODIFIED:20240327T225045Z
UID:10000474-1713261600-1713265200@brain.uci.edu
SUMMARY:Weizhe Hong\, Ph.D.
DESCRIPTION:Neural Basis of Prosocial Behavior \nThe Center for Neural Circuit Mapping (CNCM) will host Dr. Weizhe Hong\, a professor of biological chemistry and neurobiology at the University of California\, Los Angeles.
URL:https://brain.uci.edu/event/weizhe-hong-phd-2/
LOCATION:Interdisciplinary Science and Engineering Building (ISEB) and Virtually Via Zoom\, 419 Physical Sciences Quad\, Irvine\, 92697\, United States
ATTACH;FMTTYPE=image/png:https://brain.uci.edu/wp-content/uploads/sites/49/2024/02/Untitled-design-18.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20240416T110000
DTEND;TZID=America/Los_Angeles:20240416T120000
DTSTAMP:20260420T085715
CREATED:20240327T215151Z
LAST-MODIFIED:20240327T221827Z
UID:10000513-1713265200-1713268800@brain.uci.edu
SUMMARY:Semir Zeki\, FMedSci\, FRS
DESCRIPTION:Join the Center for the Neurobiology of Learning and Memory (CNLM) for an online event featuring Dr. Semir Zeki\, professor of neuroaesthetics at University College London. This event will be held virtually via Zoom. \nThe science of beauty \n \nThe experience of beauty is something that we all seek and are prepared to expend considerable energy and much money in trying to acquire. But what does it entail neurobiologically? If it is a subjective experience\, can it ever be measured? Are there\, or can there be\, any set of characteristics that render objects beautiful\, irrespective of culture and upbringing?I will address these questions from a neurobiological perspective. I will show that there cannot be a single characteristic or a single set of characteristics that can render any and every object beautiful because of the way in which our brains are organized to perceive the world. I will also show that there are\, in the perception of different attributes such as visual motion\, faces and bodies\, criteria which are not culture or education bound which can be said to enhance their beauty and to be critical to the experience of beauty when viewing them. Finally\, I will show that all works that are experienced as beautiful\, regardless of source (i.e. whether visual or musical or highly cognitive – as with mathematical beauty)\, have\, as a correlate\, activity in a specific part of the reward system of the emotional brain\, although the neural route used to reach that part of the brain varies\, depending on what is perceived. The intensity of activity there bears a quantitative relationship to the declared intensity of the experience of beauty\, thus enabling us to detect and quantify the neural correlates of a subjective experience.
URL:https://brain.uci.edu/event/semir-zeki-fmedsci-frs/
LOCATION:Zoom\, Irvine\, CA\, 92697\, United States
CATEGORIES:Faculty,Scientific,Staff,Students,Students, Faculty, Staff Only
ATTACH;FMTTYPE=image/png:https://brain.uci.edu/wp-content/uploads/sites/49/2024/03/Semir-Zeki.png
ORGANIZER;CN="UCI Center for the Neurobiology of Learning and Memory":MAILTO:memory@uci.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20240419T160000
DTEND;TZID=America/Los_Angeles:20240419T170000
DTSTAMP:20260420T085715
CREATED:20240409T161100Z
LAST-MODIFIED:20240409T164744Z
UID:10000517-1713542400-1713546000@brain.uci.edu
SUMMARY:Robert Malenka\, MD\, PhD
DESCRIPTION:“Serotonin and Sociability: From Mouse to Man” \n \n  \nRobert Malenka\, MD\, PhD\nPritzker Professor of Psychiatry and \nBehavioral Sciences\nStanford University \n  \n  \nThe MSTP Distinguished Lecture Series is proud to announce the next and final speaker for the 2023-2024 academic year\, Dr. Robert Malenka\, Pritzker Professor of Psychiatry and Behavioral Sciences at Stanford University​​​​​. Please see below for event registration. \nDr. Malenka’s work focuses on elucidating the mechanisms underlying the action of neurotransmitters in the mammalian brain and the molecular mechanisms by which neural circuits are reorganized by experience. His many contributions over the last 30 years have laid the groundwork for a more sophisticated understanding of the mechanisms by which neurons communicate and the adaptations in synaptic communication which underlie all behavior. He was trained as both a clinical psychiatrist and cellular neurobiologist and has been at the forefront of helping to apply the knowledge gained from basic neuroscience research to the treatment and prevention of major brain and behavior disorders. \nWe look forward to seeing you there!
URL:https://brain.uci.edu/event/robert-malenka-md-phd/
LOCATION:Thorp Conference Center\, Gross Hall 4th Floor or Telecast: Via Zoom\, 845 Health Sciences Rd\, Irvine\, 92617\, United States
ATTACH;FMTTYPE=image/png:https://brain.uci.edu/wp-content/uploads/sites/49/2024/04/Untitled-design-13.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20240423T110000
DTEND;TZID=America/Los_Angeles:20240423T120000
DTSTAMP:20260420T085715
CREATED:20231009T220619Z
LAST-MODIFIED:20240313T230915Z
UID:10000436-1713870000-1713873600@brain.uci.edu
SUMMARY:Laura Colgin\, Ph.D.
DESCRIPTION:CNLM Colloquium Series \nJoin the Center for the Neurobiology of Learning and Memory (CNLM) for a hybrid event featuring Dr. Laura Colgin\, professor of neuroscience at the University of Texas at Austin. This event will be held in-person in the Herklotz Conference Center and virtually via Zoom. \nHippocampal place cell responses to spatial and non-spatial information \n \nDescription: \nThe hippocampus is a key brain network for episodic memory. Place cells are neurons in the hippocampus that fire in specific spatial locations known as place fields. This spatially selective firing is thought to code the “where” component of episodic memory. Yet\, episodic memories contain nonspatial information also. This talk will present results showing how different populations of hippocampal place cells respond to nonspatial aspects of an experience\, such as social stimuli or motivational context. The results may help explain how the hippocampus integrates different aspects of an experience into a coherent episodic memory.
URL:https://brain.uci.edu/event/laura-colgin-ph-d/
LOCATION:CNLM Herklotz Conference Center and Virtually via Zoom
CATEGORIES:Faculty,Scientific,Staff,Students,Students, Faculty, Staff Only
ATTACH;FMTTYPE=image/jpeg:https://brain.uci.edu/wp-content/uploads/sites/49/2023/10/Laura-Colgin.jpg
ORGANIZER;CN="UCI Center for the Neurobiology of Learning and Memory":MAILTO:memory@uci.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20240426T110000
DTEND;TZID=America/Los_Angeles:20240426T120000
DTSTAMP:20260420T085715
CREATED:20240402T181623Z
LAST-MODIFIED:20240402T181623Z
UID:10000516-1714129200-1714132800@brain.uci.edu
SUMMARY:UCI CFAR-DS Research Seminar Series
DESCRIPTION:The CFAR-DS Research Seminar Series hosts scientists from UC Irvine and beyond who conduct research focused on Down syndrome\, including research ranging from human participants to animal models. This seminar series is intended for scientists\, although all are welcome to attend. Elizabeth Fisher\, PhD is Professor of Neurogenetics at the Institute of Neurology in Queen Square\, University College London (UCL). She has an undergraduate degree from Oxford\, and a PhD from Imperial College London. Her lab focuses on making and analyzing mouse models of neurodegeneration\, including a novel humanized model of Down syndrome (trisomy 21) and humanized SOD1\, FUS and TDP-43 models of ALS. Her presentation will address how humans and mice are related by just 75 million years of evolution\, and scientists work with tailored mouse models to understand human genetic disorders\, including Down syndrome. Dr. Fisher will show that we can understand clinical features of DS and move towards translation by working with specific mouse models.
URL:https://brain.uci.edu/event/uci-cfar-ds-research-seminar-series/
LOCATION:Zoom\, Irvine\, CA\, 92697\, United States
CATEGORIES:Scientific
ATTACH;FMTTYPE=image/png:https://brain.uci.edu/wp-content/uploads/sites/49/2024/04/CFAR_DS-_Seminar_Fisher_April2024_.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20240430T100000
DTEND;TZID=America/Los_Angeles:20240430T110000
DTSTAMP:20260420T085715
CREATED:20240201T201916Z
LAST-MODIFIED:20240327T225747Z
UID:10000475-1714471200-1714474800@brain.uci.edu
SUMMARY:Tian Lu\, Ph.D.
DESCRIPTION:Spatially resolved single-cell epigenomics and functional genomics \nThe Center for Neural Circuit Mapping (CNCM) will host Dr. Tian Lu\, a postdoctoral fellow in chemistry and chemical biology at Harvard University.
URL:https://brain.uci.edu/event/tian-lu/
LOCATION:Interdisciplinary Science and Engineering Building (ISEB) and Virtually Via Zoom\, 419 Physical Sciences Quad\, Irvine\, 92697\, United States
CATEGORIES:Faculty,Scientific,Staff,Students,Students, Faculty, Staff Only
ATTACH;FMTTYPE=image/png:https://brain.uci.edu/wp-content/uploads/sites/49/2024/02/Untitled-design-19.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20240430T110000
DTEND;TZID=America/Los_Angeles:20240430T120000
DTSTAMP:20260420T085715
CREATED:20231009T221147Z
LAST-MODIFIED:20240325T155921Z
UID:10000437-1714474800-1714478400@brain.uci.edu
SUMMARY:Chioma Okeoma\, Ph.D.
DESCRIPTION:CNLM Colloquium Series \nJoin the Center for the Neurobiology of Learning and Memory (CNLM) for a virtual event featuring Dr. Chioma Okeoma\, associate professor of pathology\, microbiology\, and immunology at the New York Medical College. This event will be held virtually via Zoom. \nExtracellular condensates – do we have to worry about them?
URL:https://brain.uci.edu/event/chioma-okeoma-ph-d/
LOCATION:Virtual via Zoom\, CA
CATEGORIES:Faculty,Scientific,Staff,Students,Students, Faculty, Staff Only
ATTACH;FMTTYPE=image/jpeg:https://brain.uci.edu/wp-content/uploads/sites/49/2023/10/Okeoma_Headshot-250.jpg
ORGANIZER;CN="UCI Center for the Neurobiology of Learning and Memory":MAILTO:memory@uci.edu
END:VEVENT
END:VCALENDAR