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Hippocampal Inhibition, Interference and Indexing

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We have previously demonstrated an important role for adult-born dentate granule cells in resolution of memory interference in adulthood and aging.  These studies have motivated assessment of the neural circuit mechanisms by which dentate granule cells modulate memory interference to dictate discrimination and generalization.  I will discuss ongoing efforts interrogating how dentate granule cells recruit inhibitory microcircuits to govern memory interference, indexing, discrimination and generalization.

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