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Dr. Nestler is the Nash Family Professor of Neuroscience, Director of the Friedman Brain Institute and Dean for Academic and Scientific Affairs at the ICHAN School of Medicine at Mount Sinai. His laboratory studies the molecular mechanisms of drug addiction and depression in animal models. The goal of Dr. Nestler’s research is to better understand the molecular mechanisms of addiction and depression. His laboratory uses animal models of these disorders to identify the ways in which long-term exposure to drugs of abuse or stress changes the brain to lead to addiction- or depression-like syndromes. A major focus of his work is on drug- and stress-induced changes in gene expression and chromatin structure within the brain’s reward circuitry, and the mechanisms by which those lasting adaptations alter neuronal and circuit function to produce behavioral abnormalities.

Details coming soon!