The CFAR-DS Research Seminar Series hosts scientists from UC Irvine and beyond who conduct research focused on Down syndrome, including research ranging from human participants to animal models. This seminar series is intended for scientists, although all are welcome to attend.

On Friday, February 23, 2024 at 11:00 am Pacific Time please join us via Zoom for a presentation by Frances Wiseman, PhD titled “Understanding differences in Down syndrome – Alzheimer’s disease: a focus on amyloid-β formation and response.”

Frances Wiseman, PhD is Programme Leader for Animal Models at the UK Dementia Research Institute. Dr Wiseman will discuss her group’s recent research using combinations of Down syndrome and amyloid-β accumulation mouse models; to understand how additional copies of chromosome 21 genes other than APP may modulate Alzheimer’s disease development in people who have Down syndrome. This will include a discussion of Mumford et al 2022, PMID: 35835549 and recent follow-up unpublished data examining the interferon amyloid-β response in a new mouse model of Down syndrome-Alzheimer’s disease.