The CFAR-DS Research Seminar Series hosts scientists from UC Irvine and beyond who conduct research focused on Down syndrome, including research ranging from human participants to animal models. This seminar series is intended for scientists, although all are welcome to attend. Elizabeth Fisher, PhD is Professor of Neurogenetics at the Institute of Neurology in Queen Square, University College London (UCL). She has an undergraduate degree from Oxford, and a PhD from Imperial College London. Her lab focuses on making and analyzing mouse models of neurodegeneration, including a novel humanized model of Down syndrome (trisomy 21) and humanized SOD1, FUS and TDP-43 models of ALS. Her presentation will address how humans and mice are related by just 75 million years of evolution, and scientists work with tailored mouse models to understand human genetic disorders, including Down syndrome. Dr. Fisher will show that we can understand clinical features of DS and move towards translation by working with specific mouse models.