Interneurons and the control of memory precision

Inhibitory interneurons govern the sparse activation of principal cells that permits appropriate behaviors, and they are activated during specific memory processes. Our recent work has demonstrated important roles for interneurons in disorders of brain development and injury. These studies have motivated our ongoing efforts to understand how these cells operate at the synaptic, circuit and behavioral levels and in designing new technologies targeting specific populations of interneurons for therapy. I will discuss our recent efforts examining the role of interneurons in memory disorders and in designing cell-based therapies that enable precise manipulation of inhibitory circuits in the brain.